{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen X"],"funding":["the Program for Changjiang Scholars and Innovative Research Team in University","the Scientific Research Innovation Project in Shihezi University","the Xinjiang Science and Technology Major Project"],"pagination":["E2950"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6720801"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(16)"],"pubmed_abstract":["Utilizing a pharmacophore hybridization approach, we have designed and synthesized a novel series of 28 new heterobivalent β-carbolines. The in vitro cytotoxic potential of each compound was evaluated against the five cancer cell lines (LLC, BGC-823, CT-26, Bel-7402, and MCF-7) of different origin-murine and human, with the aim of determining the potency and selectivity of the compounds. Compound <b>8z</b> showed antitumor activities with half-maximal inhibitory concentration (IC<sub>50</sub>) values of 9.9 ± 0.9, 8.6 ± 1.4, 6.2 ± 2.5, 9.9 ± 0.5, and 5.7 ± 1.2 µM against the tested five cancer cell lines. Moreover, the effect of compound <b>8z</b> on the angiogenesis process was investigated using a chicken chorioallantoic membrane (CAM) in vivo model. At a concentration of 5 μM, compound "],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Design, Synthesis, and Biological Evaluation of Novel N-Acylhydrazone Bond Linked Heterobivalent β-Carbolines as Potential Anticancer Agents."],"pmcid":["PMC6720801"],"funding_grant_id":["IRT15R46","2016A03005-1","SHYL-YB201804"],"pubmed_authors":["Ma Q","Guo L","Fan W","Zhang J","Chen W","Chen X"],"additional_accession":[]},"is_claimable":false,"name":"Design, Synthesis, and Biological Evaluation of Novel N-Acylhydrazone Bond Linked Heterobivalent β-Carbolines as Potential Anticancer Agents.","description":"Utilizing a pharmacophore hybridization approach, we have designed and synthesized a novel series of 28 new heterobivalent β-carbolines. The in vitro cytotoxic potential of each compound was evaluated against the five cancer cell lines (LLC, BGC-823, CT-26, Bel-7402, and MCF-7) of different origin-murine and human, with the aim of determining the potency and selectivity of the compounds. Compound <b>8z</b> showed antitumor activities with half-maximal inhibitory concentration (IC<sub>50</sub>) values of 9.9 ± 0.9, 8.6 ± 1.4, 6.2 ± 2.5, 9.9 ± 0.5, and 5.7 ± 1.2 µM against the tested five cancer cell lines. Moreover, the effect of compound <b>8z</b> on the angiogenesis process was investigated using a chicken chorioallantoic membrane (CAM) in vivo model. At a concentration of 5 μM, compound ","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Aug","modification":"2026-05-06T21:32:39.752Z","creation":"2019-09-14T07:04:45Z"},"accession":"S-EPMC6720801","cross_references":{"pubmed":["31416271"],"doi":["10.3390/molecules24162950"]}}