{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Khaw-On P"],"funding":["Graduate School, Chiang Mai University","National Research Council of Thailand","Faculty of Medicine, Chiang Mai University"],"pagination":["E3953"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6720804"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(16)"],"pubmed_abstract":["Goniothalamin (GTN) is toxic to several types of cancer cells in vitro. However, its effects on non-apoptotic cell death induction of human cancer cells have been poorly documented. Here, an investigation of the anti-cancer activity of GTN and the molecular signaling pathways of non-apoptotic cell death in the invasive human breast cancer MDA-MB-231 cell line were undertaken. Apoptotic cell death was suppressed by using a pan-caspase inhibitor (Benzyloxycarbonyl-Val-Ala-Asp-[O-methyl]-fluoromethylketone), z-VAD-fmk) as a model to study whether GTN induced caspase-independent cell death. In the anoikis study, MDA-MB-231 cells were cultured on poly-(2-hydroxyethyl methacrylate)- or poly-HEMA- coated plates to mimic anoikis-resistance growth and determine whether GTN induced cell death and th"],"journal":["International journal of molecular sciences"],"pubmed_title":["Goniothalamin Induces Necroptosis and Anoikis in Human Invasive Breast Cancer MDA-MB-231 Cells."],"pmcid":["PMC6720804"],"funding_grant_id":["2018","064/2016","2013"],"pubmed_authors":["Pompimon W","Khaw-On P","Banjerdpongchai R"],"additional_accession":[]},"is_claimable":false,"name":"Goniothalamin Induces Necroptosis and Anoikis in Human Invasive Breast Cancer MDA-MB-231 Cells.","description":"Goniothalamin (GTN) is toxic to several types of cancer cells in vitro. However, its effects on non-apoptotic cell death induction of human cancer cells have been poorly documented. Here, an investigation of the anti-cancer activity of GTN and the molecular signaling pathways of non-apoptotic cell death in the invasive human breast cancer MDA-MB-231 cell line were undertaken. Apoptotic cell death was suppressed by using a pan-caspase inhibitor (Benzyloxycarbonyl-Val-Ala-Asp-[O-methyl]-fluoromethylketone), z-VAD-fmk) as a model to study whether GTN induced caspase-independent cell death. In the anoikis study, MDA-MB-231 cells were cultured on poly-(2-hydroxyethyl methacrylate)- or poly-HEMA- coated plates to mimic anoikis-resistance growth and determine whether GTN induced cell death and th","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Aug","modification":"2025-04-26T16:48:44.621Z","creation":"2019-09-14T07:04:44Z"},"accession":"S-EPMC6720804","cross_references":{"pubmed":["31416203"],"doi":["10.3390/ijms20163953"]}}