{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wong YC"],"funding":["NCI","NINDS NIH HHS","NCI NIH HHS","National Institutes of Health","NIH HHS"],"pagination":["339-354.e4"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6726396"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["50(3)"],"pubmed_abstract":["Properly regulated mitochondrial networks are essential for cellular function and implicated in multiple diseases. Mitochondria undergo fission and fusion events, but the dynamics and regulation of a third event of inter-mitochondrial contact formation remain unclear. Using super-resolution imaging, we demonstrate that inter-mitochondrial contacts frequently form and play a fundamental role in mitochondrial networks by restricting mitochondrial motility. Inter-mitochondrial contact untethering events are marked and regulated by mitochondria-lysosome contacts, which are modulated by RAB7 GTP hydrolysis. Moreover, inter-mitochondrial contact formation and untethering are further regulated by Mfn1/2 and Drp1 GTP hydrolysis, respectively. Surprisingly, endoplasmic reticulum tubules are also pr"],"journal":["Developmental cell"],"pubmed_title":["Lysosomal Regulation of Inter-mitochondrial Contact Fate and Motility in Charcot-Marie-Tooth Type 2."],"pmcid":["PMC6726396"],"funding_grant_id":["K99 NS109252","F32 NS101778","T32 NS041234","S10 OD016342","1S10OD016342-01","P30 CA060553","R01 NS076054"],"pubmed_authors":["Peng W","Krainc D","Wong YC"],"additional_accession":[]},"is_claimable":false,"name":"Lysosomal Regulation of Inter-mitochondrial Contact Fate and Motility in Charcot-Marie-Tooth Type 2.","description":"Properly regulated mitochondrial networks are essential for cellular function and implicated in multiple diseases. Mitochondria undergo fission and fusion events, but the dynamics and regulation of a third event of inter-mitochondrial contact formation remain unclear. Using super-resolution imaging, we demonstrate that inter-mitochondrial contacts frequently form and play a fundamental role in mitochondrial networks by restricting mitochondrial motility. Inter-mitochondrial contact untethering events are marked and regulated by mitochondria-lysosome contacts, which are modulated by RAB7 GTP hydrolysis. Moreover, inter-mitochondrial contact formation and untethering are further regulated by Mfn1/2 and Drp1 GTP hydrolysis, respectively. Surprisingly, endoplasmic reticulum tubules are also pr","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Aug","modification":"2025-04-19T04:28:36.864Z","creation":"2020-09-11T07:23:25Z"},"accession":"S-EPMC6726396","cross_references":{"pubmed":["31231042"],"doi":["10.1016/j.devcel.2019.05.033"]}}