{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Blair AB"],"funding":["National Cancer Institute","NCI NIH HHS","Sidney Kimmel Comprehensive Cancer Center","NIH"],"pagination":["5351-5363"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6726532"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(17)"],"pubmed_abstract":["<h4>Purpose</h4>Myeloid cells are a prominent immunosuppressive component within the stroma of pancreatic ductal adenocarcinoma (PDAC). Previously, targeting myeloid cells has had limited success. Here, we sought to target the myeloid cells through modifying a specific stromal component.<h4>Experimental design</h4>A murine model of metastatic PDAC treated with an irradiated whole-cell PDAC vaccine and PDAC specimens from patients treated with the same type of vaccine were used to assess the immune-modulating effect of stromal hyaluronan (HA) degradation by PEGPH20.<h4>Results</h4>Targeting stroma by degrading HA with PEGPH20 in combination with vaccine decreases CXCL12/CXCR4/CCR7 immunosuppressive signaling axis expression in cancer-associated fibroblasts, myeloid, and CD8<sup>+</sup> T ce"],"journal":["Clinical cancer research : an official journal of the American Association for Cancer Research"],"pubmed_title":["Dissecting the Stromal Signaling and Regulation of Myeloid Cells and Memory Effector T Cells in Pancreatic Cancer."],"pmcid":["PMC6726532"],"funding_grant_id":["P30 CA006973","T32 CA126607","R01 CA197296","R01 CA169702","K23 CA148964","P50 CA062924"],"pubmed_authors":["Saung MT","He J","Lokker N","Wolfgang CL","Coussens LM","Burkhart RA","Blouw B","Jaffee EM","Blair AB","Armstrong TD","Tsujikawa T","Zheng L","Muth ST","Kim VM"],"additional_accession":[]},"is_claimable":false,"name":"Dissecting the Stromal Signaling and Regulation of Myeloid Cells and Memory Effector T Cells in Pancreatic Cancer.","description":"<h4>Purpose</h4>Myeloid cells are a prominent immunosuppressive component within the stroma of pancreatic ductal adenocarcinoma (PDAC). Previously, targeting myeloid cells has had limited success. Here, we sought to target the myeloid cells through modifying a specific stromal component.<h4>Experimental design</h4>A murine model of metastatic PDAC treated with an irradiated whole-cell PDAC vaccine and PDAC specimens from patients treated with the same type of vaccine were used to assess the immune-modulating effect of stromal hyaluronan (HA) degradation by PEGPH20.<h4>Results</h4>Targeting stroma by degrading HA with PEGPH20 in combination with vaccine decreases CXCL12/CXCR4/CCR7 immunosuppressive signaling axis expression in cancer-associated fibroblasts, myeloid, and CD8<sup>+</sup> T ce","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Sep","modification":"2026-05-04T10:08:43.744Z","creation":"2020-09-09T07:06:29Z"},"accession":"S-EPMC6726532","cross_references":{"pubmed":["31186314"],"doi":["10.1158/1078-0432.ccr-18-4192","10.1158/1078-0432.CCR-18-4192"]}}