biostudies-literatureLiu YTNIH National Eye InstituteNEI NIH HHSNational Cancer InstituteNCI NIH HHSCancer Prevention and Research Institute of Texas1854-1866https://www.ebi.ac.uk/biostudies/studies/S-EPMC6726575biostudies-literatureUnknown17(9)Disruption of the <i>CDKN2A</i> (<i>INK4A/ARF</i>) and <i>B</i> (<i>INK4B</i>) genes, which encode three function-independent tumor suppressors, is one of the most common events in human cancer. Because their relative importance in tumor prevention appears to be species- and context-specific, studying their regulation can shed light on mechanisms by which they are bypassed in malignant transformation. We previously unveiled a new pathway in which TGFβ selectively induces <i>Arf</i> at mouse <i>Cdkn2a</i> in eye development and cultured fibroblasts. As TGFβ signaling is often derailed in cancer development or progression, we investigated its control of <i>CDKN2A/B</i> in human cancer. Computational analyses of sequencing and array data from nearly 11,000 patients with cancer in TCGA showed Molecular cancer research : MCRIdentification of <i>De Novo</i> Enhancers Activated by TGFβ to Drive Expression of <i>CDKN2A</i> and <i>B</i> in HeLa Cells.PMC6726575R01 EY019942CA142543RP120685-P2RP180319P30 CA142543Xu LSkapek SXLiu JLiem PZheng YHooks JCZhou QBennett LLiu YTfalseIdentification of <i>De Novo</i> Enhancers Activated by TGFβ to Drive Expression of <i>CDKN2A</i> and <i>B</i> in HeLa Cells.Disruption of the <i>CDKN2A</i> (<i>INK4A/ARF</i>) and <i>B</i> (<i>INK4B</i>) genes, which encode three function-independent tumor suppressors, is one of the most common events in human cancer. Because their relative importance in tumor prevention appears to be species- and context-specific, studying their regulation can shed light on mechanisms by which they are bypassed in malignant transformation. We previously unveiled a new pathway in which TGFβ selectively induces <i>Arf</i> at mouse <i>Cdkn2a</i> in eye development and cultured fibroblasts. As TGFβ signaling is often derailed in cancer development or progression, we investigated its control of <i>CDKN2A/B</i> in human cancer. Computational analyses of sequencing and array data from nearly 11,000 patients with cancer in TCGA showed 2019-01-01T00:00:00Z2019 Sep2026-05-04T10:08:50.899Z2020-05-22T11:28:10ZS-EPMC67265753118969010.1158/1541-7786.mcr-19-028910.1158/1541-7786.MCR-19-0289