{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kapadia BB"],"funding":["BLRD VA","NCI NIH HHS"],"pagination":["1475-1483"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6727985"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(9)"],"pubmed_abstract":["Cancer cells revamp the regulatory processes that control translation to induce tumor-specific translational programs that can adapt to a hostile microenvironment as well as withstand anticancer therapeutics. Translational initiation has been established as a common downstream effector of numerous deregulated signaling pathways that together culminate in prooncogenic expression. Other mechanisms, including ribosomal stalling and stress granule assembly, also appear to be rewired in the malignant phenotype. Therefore, better understanding of the underlying perturbations driving oncogenic translation in the transformed state will provide innovative therapeutic opportunities. This review highlights deubiquitinating enzymes that are activated/dysregulated in hematologic malignancies, thereby altering the translational output and contributing to tumorigenesis."],"journal":["Molecular cancer therapeutics"],"pubmed_title":["DUBbing Down Translation: The Functional Interaction of Deubiquitinases with the Translational Machinery."],"pmcid":["PMC6727985"],"funding_grant_id":["I01 BX002990","R01 CA164311"],"pubmed_authors":["Kapadia BB","Gartenhaus RB"],"additional_accession":[]},"is_claimable":false,"name":"DUBbing Down Translation: The Functional Interaction of Deubiquitinases with the Translational Machinery.","description":"Cancer cells revamp the regulatory processes that control translation to induce tumor-specific translational programs that can adapt to a hostile microenvironment as well as withstand anticancer therapeutics. Translational initiation has been established as a common downstream effector of numerous deregulated signaling pathways that together culminate in prooncogenic expression. Other mechanisms, including ribosomal stalling and stress granule assembly, also appear to be rewired in the malignant phenotype. Therefore, better understanding of the underlying perturbations driving oncogenic translation in the transformed state will provide innovative therapeutic opportunities. This review highlights deubiquitinating enzymes that are activated/dysregulated in hematologic malignancies, thereby altering the translational output and contributing to tumorigenesis.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Sep","modification":"2020-09-26T07:07:02Z","creation":"2020-05-22T11:33:49Z"},"accession":"S-EPMC6727985","cross_references":{"pubmed":["31481479"],"doi":["10.1158/1535-7163.mct-19-0307","10.1158/1535-7163.MCT-19-0307"]}}