{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Geurtsen ML"],"funding":["European Research Council","Dutch Research Council (NWO)","Ministerie van Volksgezondheid, Welzijn en Sport","Diabetes Fonds","ZonMw","Hartstichting"],"pagination":["1880-1890"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6731335"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["62(10)"],"pubmed_abstract":["<h4>Aims/hypothesis</h4>The study aimed to assess the associations of maternal early-pregnancy blood glucose levels with fetal growth throughout pregnancy and the risks of adverse birth outcomes.<h4>Methods</h4>In a population-based prospective cohort study among 6116 pregnant women, maternal non-fasting glucose levels were measured in blood plasma at a median 13.2 weeks of gestation (95% range 9.6-17.6). We measured fetal growth by ultrasound in each pregnancy period. We obtained information about birth outcomes from medical records and maternal sociodemographic and lifestyle factors from questionnaires.<h4>Results</h4>Higher maternal early-pregnancy non-fasting glucose levels were associated with altered fetal growth patterns, characterised by decreased fetal growth rates in mid-pregnancy and increased fetal growth rates from late pregnancy onwards, resulting in an increased length and weight at birth (p ≤0.05 for all). A weaker association of maternal early-pregnancy non-fasting glucose levels with fetal head circumference growth rates was present. Higher maternal early-pregnancy non-fasting glucose levels were also associated with an increased risk of delivering a large-for-gestational-age infant, but decreased risk of delivering a small-for-gestational-age infant (OR 1.28 [95% CI 1.16, 1.41], OR 0.88 [95% CI 0.79, 0.98] per mmol/l increase in maternal early-pregnancy non-fasting glucose levels, respectively). These associations were not explained by maternal sociodemographic factors, lifestyle factors or BMI. Maternal early-pregnancy non-fasting glucose levels were not associated with preterm birth or delivery complications.<h4>Conclusions/interpretation</h4>Higher maternal early-pregnancy non-fasting glucose levels are associated with decreased fetal growth rates in mid-pregnancy and increased fetal growth rates from late pregnancy onwards, and an increased risk of delivering a large-for-gestational-age infant. Future preventive strategies need to focus on screening for an impaired maternal glucose metabolism from preconception and early pregnancy onwards to improve birth outcomes."],"journal":["Diabetologia"],"pubmed_title":["High maternal early-pregnancy blood glucose levels are associated with altered fetal growth and increased risk of adverse birth outcomes."],"pmcid":["PMC6731335"],"funding_grant_id":["ERC-2014-CoG-648916","2017T013","2017.81.002","648916","VIDI 016.136.361"],"pubmed_authors":["Voerman E","Jaddoe VWV","Gaillard R","van Soest EEL","Geurtsen ML","Steegers EAP"],"additional_accession":[]},"is_claimable":false,"name":"High maternal early-pregnancy blood glucose levels are associated with altered fetal growth and increased risk of adverse birth outcomes.","description":"<h4>Aims/hypothesis</h4>The study aimed to assess the associations of maternal early-pregnancy blood glucose levels with fetal growth throughout pregnancy and the risks of adverse birth outcomes.<h4>Methods</h4>In a population-based prospective cohort study among 6116 pregnant women, maternal non-fasting glucose levels were measured in blood plasma at a median 13.2 weeks of gestation (95% range 9.6-17.6). We measured fetal growth by ultrasound in each pregnancy period. We obtained information about birth outcomes from medical records and maternal sociodemographic and lifestyle factors from questionnaires.<h4>Results</h4>Higher maternal early-pregnancy non-fasting glucose levels were associated with altered fetal growth patterns, characterised by decreased fetal growth rates in mid-pregnancy and increased fetal growth rates from late pregnancy onwards, resulting in an increased length and weight at birth (p ≤0.05 for all). A weaker association of maternal early-pregnancy non-fasting glucose levels with fetal head circumference growth rates was present. Higher maternal early-pregnancy non-fasting glucose levels were also associated with an increased risk of delivering a large-for-gestational-age infant, but decreased risk of delivering a small-for-gestational-age infant (OR 1.28 [95% CI 1.16, 1.41], OR 0.88 [95% CI 0.79, 0.98] per mmol/l increase in maternal early-pregnancy non-fasting glucose levels, respectively). These associations were not explained by maternal sociodemographic factors, lifestyle factors or BMI. Maternal early-pregnancy non-fasting glucose levels were not associated with preterm birth or delivery complications.<h4>Conclusions/interpretation</h4>Higher maternal early-pregnancy non-fasting glucose levels are associated with decreased fetal growth rates in mid-pregnancy and increased fetal growth rates from late pregnancy onwards, and an increased risk of delivering a large-for-gestational-age infant. Future preventive strategies need to focus on screening for an impaired maternal glucose metabolism from preconception and early pregnancy onwards to improve birth outcomes.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Oct","modification":"2024-12-03T15:29:15.224Z","creation":"2019-10-03T07:03:07Z"},"accession":"S-EPMC6731335","cross_references":{"pubmed":["31392381"],"doi":["10.1007/s00125-019-4957-3"]}}