{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(20)"],"submitter":["Hoffmann SHL"],"pubmed_abstract":["Myeloid-derived suppressor cells (MDSCs) are immunosuppressive cells of the myeloid compartment and major players in the tumor microenvironment (TME). With increasing numbers of studies describing MDSC involvement in cancer immune escape, cancer metastasis and the dampening of immunotherapy responses, MDSCs are of high interest in current cancer therapy research. Although heavily investigated in the last decades, the <i>in vivo</i> migration dynamics of MDSC subpopulations in tumor- or metastases-bearing mice have not yet been studied extensively. Therefore, we have modified our previously reported intracellular cell labeling method and applied it to <i>in vitro</i> generated MDSCs for the quantitative <i>in vivo</i> monitoring of MDSC migration in primary and metastatic cancer. MDSC migra"],"journal":["Theranostics"],"pagination":["5869-5885"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6735369"],"repository":["biostudies-literature"],"pubmed_title":["Visualization and quantification of <i>in vivo</i> homing kinetics of myeloid-derived suppressor cells in primary and metastatic cancer."],"pmcid":["PMC6735369"],"pubmed_authors":["Reischl G","Hoffmann SHL","Oz HH","Sceneay JE","Fehrenbacher B","Poxleitner M","Schaller M","Maurer A","Moller A","Fuchs K","Reck DI","Hartl D","Kneilling M","Ehrlichmann W","Griessinger CM","Pichler BJ"],"additional_accession":[]},"is_claimable":false,"name":"Visualization and quantification of <i>in vivo</i> homing kinetics of myeloid-derived suppressor cells in primary and metastatic cancer.","description":"Myeloid-derived suppressor cells (MDSCs) are immunosuppressive cells of the myeloid compartment and major players in the tumor microenvironment (TME). With increasing numbers of studies describing MDSC involvement in cancer immune escape, cancer metastasis and the dampening of immunotherapy responses, MDSCs are of high interest in current cancer therapy research. Although heavily investigated in the last decades, the <i>in vivo</i> migration dynamics of MDSC subpopulations in tumor- or metastases-bearing mice have not yet been studied extensively. Therefore, we have modified our previously reported intracellular cell labeling method and applied it to <i>in vitro</i> generated MDSCs for the quantitative <i>in vivo</i> monitoring of MDSC migration in primary and metastatic cancer. MDSC migra","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2025-04-04T08:30:09.13Z","creation":"2019-09-26T07:05:06Z"},"accession":"S-EPMC6735369","cross_references":{"pubmed":["31534525"],"doi":["10.7150/thno.33275"]}}