{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(20)"],"submitter":["Chen Z"],"pubmed_abstract":["<b>Background & Aims</b>: The use of antisense oligonucleotide-based nanosystems for the detection and regulation of tumor-related gene expression is thought to be a promising approach for cancer diagnostics and therapies. Herein, we report that a cubic-shaped iron oxide nanoparticle (IONC) core nanobeacon is capable of delivering an HSP90α mRNA-specific molecular beacon (HSP90-MB) into living cells and enhancing <i>T</i> <sub>2</sub>-weighted MR imaging in a tumor model. <b>Methods</b>: The nanobeacons were built with IONC, generation 4 poly(amidoamine) dendrimer (G4 PAMAM), Pluronic P123 (P123) and HSP90-MB labeled with a quencher (BHQ1) and a fluorophore (Alexa Fluor 488). <b>Results</b>: After internalization by malignant cells overexpressing HSP90α, the fluorescence of the nanobeacon "],"journal":["Theranostics"],"pagination":["5784-5796"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6735378"],"repository":["biostudies-literature"],"pubmed_title":["Dendrimer-Functionalized Superparamagnetic Nanobeacons for Real-Time Detection and Depletion of HSP90α mRNA and MR Imaging."],"pmcid":["PMC6735378"],"pubmed_authors":["Yang H","Peng Y","Xie X","Feng Y","Qin X","Wu C","Liu Y","Li S","Zhu J","Chen Z","Li T","Zheng C","You F"],"additional_accession":[]},"is_claimable":false,"name":"Dendrimer-Functionalized Superparamagnetic Nanobeacons for Real-Time Detection and Depletion of HSP90α mRNA and MR Imaging.","description":"<b>Background & Aims</b>: The use of antisense oligonucleotide-based nanosystems for the detection and regulation of tumor-related gene expression is thought to be a promising approach for cancer diagnostics and therapies. Herein, we report that a cubic-shaped iron oxide nanoparticle (IONC) core nanobeacon is capable of delivering an HSP90α mRNA-specific molecular beacon (HSP90-MB) into living cells and enhancing <i>T</i> <sub>2</sub>-weighted MR imaging in a tumor model. <b>Methods</b>: The nanobeacons were built with IONC, generation 4 poly(amidoamine) dendrimer (G4 PAMAM), Pluronic P123 (P123) and HSP90-MB labeled with a quencher (BHQ1) and a fluorophore (Alexa Fluor 488). <b>Results</b>: After internalization by malignant cells overexpressing HSP90α, the fluorescence of the nanobeacon ","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2025-04-04T08:30:14.322Z","creation":"2019-09-26T07:05:06Z"},"accession":"S-EPMC6735378","cross_references":{"pubmed":["31534519"],"doi":["10.7150/thno.36545"]}}