{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Muraleedharan CK"],"funding":["NEI NIH HHS"],"pagination":["347-358"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6738186"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(4)"],"pubmed_abstract":["Macrophages (Mϕ) are an important component of the innate immune system; they play critical roles in the first line of defense to pathogen invasion and modulate adaptive immunity. MicroRNAs (miRNAs) are a newly recognized, important level of gene expression regulation. However, their roles in the regulation of Mϕ and the immune system are still not fully understood. In this report, we provide evidence that the conserved miR-183/96/182 cluster (miR-183/96/182) modulates Mϕ function in their production of reactive nitrogen (RNS) and oxygen species (ROS) and their inflammatory response to Pseudomonas aeruginosa (PA) infection and/or lipopolysaccharide (LPS) treatment. We show that knockdown of miR-183/96/182 results in decreased production of multiple proinflammatory cytokines in response to "],"journal":["Journal of innate immunity"],"pubmed_title":["The miR-183/96/182 Cluster Regulates Macrophage Functions in Response to Pseudomonas aeruginosa."],"pmcid":["PMC6738186"],"funding_grant_id":["P30 EY004068","R01 EY026059","R01 EY016058"],"pubmed_authors":["Francis R","Zmejkoski A","McClellan SA","Hazlett LD","Xu S","Muraleedharan CK","Ekanayaka SA"],"additional_accession":[]},"is_claimable":false,"name":"The miR-183/96/182 Cluster Regulates Macrophage Functions in Response to Pseudomonas aeruginosa.","description":"Macrophages (Mϕ) are an important component of the innate immune system; they play critical roles in the first line of defense to pathogen invasion and modulate adaptive immunity. MicroRNAs (miRNAs) are a newly recognized, important level of gene expression regulation. However, their roles in the regulation of Mϕ and the immune system are still not fully understood. In this report, we provide evidence that the conserved miR-183/96/182 cluster (miR-183/96/182) modulates Mϕ function in their production of reactive nitrogen (RNS) and oxygen species (ROS) and their inflammatory response to Pseudomonas aeruginosa (PA) infection and/or lipopolysaccharide (LPS) treatment. We show that knockdown of miR-183/96/182 results in decreased production of multiple proinflammatory cytokines in response to ","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2025-04-19T09:40:31.227Z","creation":"2019-10-11T07:04:28Z"},"accession":"S-EPMC6738186","cross_references":{"pubmed":["30625496"],"doi":["10.1159/000495472"]}}