biostudies-literatureChilet-Rosell ECIBER en Epidemiología y Salud PúblicaFondo de investigaciones Sanitarias. Instituto de Salud Carlos III (Plan Nacional de I+D+I). co-funded by the Fondo Europeo de Desarrollo Regionale0221134https://www.ebi.ac.uk/biostudies/studies/S-EPMC6738604biostudies-literatureUnknown14(9)<h4>Objectives</h4>To determine the factors associated with lung cancer diagnosis and mortality after detecting a solitary pulmonary nodule (SPN) in routine clinical practice, in men and in women for both chest radiograph and CT.<h4>Materials and methods</h4>A 5-year follow-up of a retrospective cohort of of 25,422 (12,594 men, 12,827 women) patients aged ≥35 years referred for chest radiograph or CT in two hospitals in Spain (2010-2011). SPN were detected in 893 (546 men, 347 women) patients. We estimated the cumulative incidence of lung cancer at 5-years, the association of patient and nodule characteristics with SPN malignancy using Poisson logistic regression, stratifying by sex and type of imaging test. We calculated lung cancer specific mortality rate by sex and SPN detection and hazPloS oneThe determinants of lung cancer after detecting a solitary pulmonary nodule are different in men and women, for both chest radiograph and CT.PMC6738604CB06/02/0008PS 09/0477Hernandez-Aguado IVilar JDomingo MLGonzalez-Alvarez ILumbreras BChilet-Rosell EPastor-Valero MLorente-Fernandez FParker LASalinas-Serrano JMfalseThe determinants of lung cancer after detecting a solitary pulmonary nodule are different in men and women, for both chest radiograph and CT.<h4>Objectives</h4>To determine the factors associated with lung cancer diagnosis and mortality after detecting a solitary pulmonary nodule (SPN) in routine clinical practice, in men and in women for both chest radiograph and CT.<h4>Materials and methods</h4>A 5-year follow-up of a retrospective cohort of of 25,422 (12,594 men, 12,827 women) patients aged ≥35 years referred for chest radiograph or CT in two hospitals in Spain (2010-2011). SPN were detected in 893 (546 men, 347 women) patients. We estimated the cumulative incidence of lung cancer at 5-years, the association of patient and nodule characteristics with SPN malignancy using Poisson logistic regression, stratifying by sex and type of imaging test. We calculated lung cancer specific mortality rate by sex and SPN detection and haz2019-01-01T00:00:00Z20192025-05-29T20:23:08.151Z2025-05-29T20:23:08.151ZS-EPMC67386043150955010.1371/journal.pone.0221134