biostudies-literatureGovaert GDePuySynthese027772https://www.ebi.ac.uk/biostudies/studies/S-EPMC6738705biostudies-literatureUnknown9(9)<h4>Introduction</h4>The optimal diagnostic imaging strategy for fracture-related infection (FRI) remains to be established. In this prospective study, the three commonly used advanced imaging techniques for diagnosing FRI will be compared. Primary endpoints are (1) determining the overall diagnostic performances of white blood cell (WBC) scintigraphy, fluorodeoxyglucose positron emission tomography (FDG-PET) and magnetic resonance imaging (MRI) in patients with suspected FRI and (2) establishing the most accurate imaging strategy for diagnosing FRI.<h4>Methods and analysis</h4>This study is a non-randomised, partially blinded, prospective cohort study involving two level 1 trauma centres in The Netherlands. All adult patients who require advanced medical imaging for suspected FRI are eligBMJ openThe accuracy of diagnostic Imaging techniques in patients with a suspected Fracture-related Infection (IFI) trial: study protocol for a prospective multicenter cohort study.PMC6738705DPS-TCMF-2019-014Kwee TCLeenen LBosch PVogely HCIJpma FGlaudemans AReininga IJutte PCGovaert GDierckx RHobbelink Mde Jong PAfalseThe accuracy of diagnostic Imaging techniques in patients with a suspected Fracture-related Infection (IFI) trial: study protocol for a prospective multicenter cohort study.<h4>Introduction</h4>The optimal diagnostic imaging strategy for fracture-related infection (FRI) remains to be established. In this prospective study, the three commonly used advanced imaging techniques for diagnosing FRI will be compared. Primary endpoints are (1) determining the overall diagnostic performances of white blood cell (WBC) scintigraphy, fluorodeoxyglucose positron emission tomography (FDG-PET) and magnetic resonance imaging (MRI) in patients with suspected FRI and (2) establishing the most accurate imaging strategy for diagnosing FRI.<h4>Methods and analysis</h4>This study is a non-randomised, partially blinded, prospective cohort study involving two level 1 trauma centres in The Netherlands. All adult patients who require advanced medical imaging for suspected FRI are elig2019-01-01T00:00:00Z2019 Sep2025-05-29T20:23:19.388Z2025-05-29T20:23:19.388ZS-EPMC67387053150110110.1136/bmjopen-2018-027772