{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chalasani SH"],"funding":["NINDS NIH HHS"],"pagination":["4601-12"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6740796"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(11)"],"pubmed_abstract":["The chemokine receptor CXCR4 is expressed in the embryonic and mature CNS, yet its normal physiological function in neurons remains obscure. Here, we show that its cognate chemokine, stromal cell-derived factor-1 (SDF-1), promotes the survival of cultured embryonic retinal ganglion cell neurons even in the absence of other neurotrophic factors. This survival effect is mediated primarily through a cAMP-dependent pathway that acts through protein kinase A and MAP kinase. Addition of SDF-1 to a human neuronal cell line induces phosphorylation of p44/p42 MAP kinase and GSK3beta. Mouse embryos lacking the CXCR4 receptor have a reduced number of retinal ganglion cells. The ligand of CXCR4, SDF-1, may therefore provide generalized trophic support to neurons during their development and maturation"],"journal":["The Journal of neuroscience : the official journal of the Society for Neuroscience"],"pubmed_title":["The chemokine stromal cell-derived factor-1 promotes the survival of embryonic retinal ganglion cells."],"pmcid":["PMC6740796"],"funding_grant_id":["R01 NS026527","R01-NS26527"],"pubmed_authors":["Baribaud F","Doms RW","Littman DR","Coughlan CM","Lee VM","Raper JA","Chalasani SH","Sunshine MJ"],"additional_accession":[]},"is_claimable":false,"name":"The chemokine stromal cell-derived factor-1 promotes the survival of embryonic retinal ganglion cells.","description":"The chemokine receptor CXCR4 is expressed in the embryonic and mature CNS, yet its normal physiological function in neurons remains obscure. Here, we show that its cognate chemokine, stromal cell-derived factor-1 (SDF-1), promotes the survival of cultured embryonic retinal ganglion cell neurons even in the absence of other neurotrophic factors. This survival effect is mediated primarily through a cAMP-dependent pathway that acts through protein kinase A and MAP kinase. Addition of SDF-1 to a human neuronal cell line induces phosphorylation of p44/p42 MAP kinase and GSK3beta. Mouse embryos lacking the CXCR4 receptor have a reduced number of retinal ganglion cells. The ligand of CXCR4, SDF-1, may therefore provide generalized trophic support to neurons during their development and maturation","dates":{"release":"2003-01-01T00:00:00Z","publication":"2003 Jun","modification":"2025-04-04T12:25:43.764Z","creation":"2019-09-26T07:05:50Z"},"accession":"S-EPMC6740796","cross_references":{"pubmed":["12805300"],"doi":["10.1523/jneurosci.23-11-04601.2003","10.1523/JNEUROSCI.23-11-04601.2003"]}}