biostudies-literatureSluyter JDBritish Heart FoundationMedical Research Council921-928https://www.ebi.ac.uk/biostudies/studies/S-EPMC6742504biostudies-literatureUnknown74(4)Clustering of arterial blood pressure (BP) waveform parameters could summarize complex information into distinct elements, which could be used to investigate cumulative (nonredundant) associations. We investigated this hypothesis in a large, adult population-based study (ViDA trial [Vitamin D Assessment] trial). To interpret the clusters and evaluate their usefulness, we examined their predictors and associations with cardiovascular events. In 4253 adults (mean age 65 years; 55% male) without a prior cardiovascular event, suprasystolic oscillometry was performed, yielding aortic pressure waveforms and several hemodynamic parameters. Participants were followed up for 4.6 years (median), accruing 300 cardiovascular events. Principal component analysis reduced 14 arterial waveform parameters Hypertension (Dallas, Tex. : 1979)Identification of Distinct Arterial Waveform Clusters and a Longitudinal Evaluation of Their Clinical Usefulness.PMC6742504CS/15/6/31468PG/17/90/33415MC_UU_12019/1PG/15/75/31748CS/13/1/30327PG/13/6/29934Hughes ADHametner BParker KHThom SAMWassertheurer SSluyter JDScragg RCamargo CAfalseIdentification of Distinct Arterial Waveform Clusters and a Longitudinal Evaluation of Their Clinical Usefulness.Clustering of arterial blood pressure (BP) waveform parameters could summarize complex information into distinct elements, which could be used to investigate cumulative (nonredundant) associations. We investigated this hypothesis in a large, adult population-based study (ViDA trial [Vitamin D Assessment] trial). To interpret the clusters and evaluate their usefulness, we examined their predictors and associations with cardiovascular events. In 4253 adults (mean age 65 years; 55% male) without a prior cardiovascular event, suprasystolic oscillometry was performed, yielding aortic pressure waveforms and several hemodynamic parameters. Participants were followed up for 4.6 years (median), accruing 300 cardiovascular events. Principal component analysis reduced 14 arterial waveform parameters 2019-01-01T00:00:00Z2019 Oct2025-04-04T00:05:15.434Z2020-10-29T12:04:37ZS-EPMC67425043144680310.1161/hypertensionaha.119.1262510.1161/HYPERTENSIONAHA.119.12625