{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yannoutsos A"],"funding":["Institut National Du Cancer"],"pagination":["212"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6743149"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(1)"],"pubmed_abstract":["Background
Smoking is a strong risk factor for cancer and atherosclerosis. Cancer mortality, especially from lung cancer, overtakes cardiovascular (CV) death rate in patients with peripheral arterial disease (PAD). Only a few patients with lung cancer after PAD management may benefit from surgical excision. Circulating tumor cells (CTC) associated with low-dose chest CT (LDCT) may improve early cancer detection. This study focuses on a screening strategy that can address not only lung cancer but all tobacco-related cancers in this high-risk population.Methods
DETECTOR Project is a prospective cohort study in two French University hospitals. Participants are smokers or former smokers (≥30 pack-years, quitted ≤15 years), aged ≥55 to 80 years, with atherosclerotic PAD or abdom"],"journal":["BMC cardiovascular disorders"],"pubmed_title":["Peripheral arterial disease and systematic detection of circulating tumor cells: rationale and design of the DETECTOR prospective cohort study."],"pmcid":["PMC6743149"],"funding_grant_id":["2016-085"],"pubmed_authors":["Sanson H","Emmerich J","Chatellier G","Labrousse C","Tredaniel J","Zins M","Galloula A","Beaussier H","Duchatelle V","Lajonchere JP","Nasr NB","Lazareth I","Ghaffari P","Pastre J","Messas E","Damotte D","Yannoutsos A","Meyer G","Marini V","Fontaine M","Priollet P","Salmeron S","Paterlini-Brechot P","Schwering KL","Stansal A"],"additional_accession":[]},"is_claimable":false,"name":"Peripheral arterial disease and systematic detection of circulating tumor cells: rationale and design of the DETECTOR prospective cohort study.","description":"Background
Smoking is a strong risk factor for cancer and atherosclerosis. Cancer mortality, especially from lung cancer, overtakes cardiovascular (CV) death rate in patients with peripheral arterial disease (PAD). Only a few patients with lung cancer after PAD management may benefit from surgical excision. Circulating tumor cells (CTC) associated with low-dose chest CT (LDCT) may improve early cancer detection. This study focuses on a screening strategy that can address not only lung cancer but all tobacco-related cancers in this high-risk population.Methods
DETECTOR Project is a prospective cohort study in two French University hospitals. Participants are smokers or former smokers (≥30 pack-years, quitted ≤15 years), aged ≥55 to 80 years, with atherosclerotic PAD or abdom","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Sep","modification":"2025-04-05T10:14:14.448Z","creation":"2019-09-24T07:11:15Z"},"accession":"S-EPMC6743149","cross_references":{"pubmed":["31519196"],"doi":["10.1186/s12872-019-1193-1"]}}