biostudies-literatureYannoutsos AInstitut National Du Cancer212https://www.ebi.ac.uk/biostudies/studies/S-EPMC6743149biostudies-literatureUnknown19(1)<h4>Background</h4>Smoking is a strong risk factor for cancer and atherosclerosis. Cancer mortality, especially from lung cancer, overtakes cardiovascular (CV) death rate in patients with peripheral arterial disease (PAD). Only a few patients with lung cancer after PAD management may benefit from surgical excision. Circulating tumor cells (CTC) associated with low-dose chest CT (LDCT) may improve early cancer detection. This study focuses on a screening strategy that can address not only lung cancer but all tobacco-related cancers in this high-risk population.<h4>Methods</h4>DETECTOR Project is a prospective cohort study in two French University hospitals. Participants are smokers or former smokers (≥30 pack-years, quitted ≤15 years), aged ≥55 to 80 years, with atherosclerotic PAD or abdomBMC cardiovascular disordersPeripheral arterial disease and systematic detection of circulating tumor cells: rationale and design of the DETECTOR prospective cohort study.PMC67431492016-085Sanson HEmmerich JChatellier GLabrousse CTredaniel JZins MGalloula ABeaussier HDuchatelle VLajonchere JPNasr NBLazareth IGhaffari PPastre JMessas EDamotte DYannoutsos AMeyer GMarini VFontaine MPriollet PSalmeron SPaterlini-Brechot PSchwering KLStansal AfalsePeripheral arterial disease and systematic detection of circulating tumor cells: rationale and design of the DETECTOR prospective cohort study.<h4>Background</h4>Smoking is a strong risk factor for cancer and atherosclerosis. Cancer mortality, especially from lung cancer, overtakes cardiovascular (CV) death rate in patients with peripheral arterial disease (PAD). Only a few patients with lung cancer after PAD management may benefit from surgical excision. Circulating tumor cells (CTC) associated with low-dose chest CT (LDCT) may improve early cancer detection. This study focuses on a screening strategy that can address not only lung cancer but all tobacco-related cancers in this high-risk population.<h4>Methods</h4>DETECTOR Project is a prospective cohort study in two French University hospitals. Participants are smokers or former smokers (≥30 pack-years, quitted ≤15 years), aged ≥55 to 80 years, with atherosclerotic PAD or abdom2019-01-01T00:00:00Z2019 Sep2025-04-05T10:14:14.448Z2019-09-24T07:11:15ZS-EPMC67431493151919610.1186/s12872-019-1193-1