biostudies-literatureChen SLMOH | National Medical Research CouncilAgency for Science, Technology and ResearchGenome Institute of Singapore13245https://www.ebi.ac.uk/biostudies/studies/S-EPMC6744567biostudies-literatureUnknown9(1)The ST131 multilocus sequence type (MLST) of Escherichia coli is a globally successful pathogen whose dissemination is increasing rates of antibiotic resistance. Numerous global surveys have demonstrated the pervasiveness of this clone; in some regions ST131 accounts for up to 30% of all E. coli isolates. However, many regions are underrepresented in these published surveys, including Africa, South America, and Asia. We collected consecutive bloodstream E. coli isolates from three countries in Southeast Asia; ST131 was the most common MLST type. As in other studies, the C2/H30Rx clade accounted for the majority of ST131 strains. Clinical risk factors were similar to other reported studies. However, we found that nearly all of the C2 strains in this study were closely related, forming what Scientific reportsThe higher prevalence of extended spectrum beta-lactamases among Escherichia coli ST131 in Southeast Asia is driven by expansion of a single, locally prevalent subclone.PMC6744567IAF311018NMRC/OFIRG/0009/2016NMRC/CIRG/1467/2017NMRC/CIRG/1357/2013Lye DCKalimuddin SWong JGXApisarnthanarak AAtiya NVelayuthan RDOmar SFSChen SLDing YDe PPChew KLKoh THArchuleta SSuwantarat NfalseThe higher prevalence of extended spectrum beta-lactamases among Escherichia coli ST131 in Southeast Asia is driven by expansion of a single, locally prevalent subclone.The ST131 multilocus sequence type (MLST) of Escherichia coli is a globally successful pathogen whose dissemination is increasing rates of antibiotic resistance. Numerous global surveys have demonstrated the pervasiveness of this clone; in some regions ST131 accounts for up to 30% of all E. coli isolates. However, many regions are underrepresented in these published surveys, including Africa, South America, and Asia. We collected consecutive bloodstream E. coli isolates from three countries in Southeast Asia; ST131 was the most common MLST type. As in other studies, the C2/H30Rx clade accounted for the majority of ST131 strains. Clinical risk factors were similar to other reported studies. However, we found that nearly all of the C2 strains in this study were closely related, forming what 2019-01-01T00:00:00Z2019 Sep2026-05-04T18:08:05.164Z2019-10-11T07:05:26ZS-EPMC67445673151997210.1038/s41598-019-49467-5