{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chamberlain AM"],"funding":["NIA NIH HHS","Amgen, Inc.","National Institute on Aging"],"pagination":["995-1001"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6744976"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["124(7)"],"pubmed_abstract":["The purpose of this study is to describe lipid-lowering therapy (LLT) prescriptions and low-density lipoprotein cholesterol (LDL-C) monitoring in patients with diabetes mellitus (DM) with or without concomitant cardiovascular disease (CVD). Olmsted County, Minnesota residents with a first-ever diagnosis of DM or CVD (ischemic stroke/transient ischemic attack, myocardial infarction, unstable angina pectoris, or revascularization procedure) between 2005 and 2012 were classified as having DM only, CVD only, or CVD + DM. All LLT prescriptions and LDL-C measurements were obtained for 2 years after diagnosis. A total of 4,186, 2,368, and 724 patients had DM, CVD, and CVD + DM, respectively. Rates of LDL-C measurement were 1.31, 1.66, and 1.88 per person-year and 14%, 32%, and 42% of LDL-C measurements were <70 mg/dl in those with DM, CVD, and CVD + DM. Within 3 months after diagnosis, 47%, 71%, and 78% of patients with DM, CVD, and CVD + DM were prescribed LLT. Most prescriptions were for moderate-intensity statins. Under one-fifth of patients with CVD and CVD + DM were prescribed high-intensity statins. Predictors of high-intensity statin prescriptions included male sex, having CVD or CVD + DM, increasing LDL-C, and LDL-C measured more recently (2012 to 2014 vs before 2012). In conclusion, a large proportion of patients at high CVD risk are not adequately treated with LLT. Despite often being considered a risk equivalent, patients with DM have substantially lower rates of LLT prescriptions and lesser controlled LDL-C than those with CVD or CVD + DM."],"journal":["The American journal of cardiology"],"pubmed_title":["Lipid-Lowering Prescription Patterns in Patients With Diabetes Mellitus or Cardiovascular Disease."],"pmcid":["PMC6744976"],"funding_grant_id":["R01 AG034676"],"pubmed_authors":["Killian JM","Weston SA","Cohen SS","Monda KL","Chamberlain AM","Okerson T"],"additional_accession":[]},"is_claimable":false,"name":"Lipid-Lowering Prescription Patterns in Patients With Diabetes Mellitus or Cardiovascular Disease.","description":"The purpose of this study is to describe lipid-lowering therapy (LLT) prescriptions and low-density lipoprotein cholesterol (LDL-C) monitoring in patients with diabetes mellitus (DM) with or without concomitant cardiovascular disease (CVD). Olmsted County, Minnesota residents with a first-ever diagnosis of DM or CVD (ischemic stroke/transient ischemic attack, myocardial infarction, unstable angina pectoris, or revascularization procedure) between 2005 and 2012 were classified as having DM only, CVD only, or CVD + DM. All LLT prescriptions and LDL-C measurements were obtained for 2 years after diagnosis. A total of 4,186, 2,368, and 724 patients had DM, CVD, and CVD + DM, respectively. Rates of LDL-C measurement were 1.31, 1.66, and 1.88 per person-year and 14%, 32%, and 42% of LDL-C measurements were <70 mg/dl in those with DM, CVD, and CVD + DM. Within 3 months after diagnosis, 47%, 71%, and 78% of patients with DM, CVD, and CVD + DM were prescribed LLT. Most prescriptions were for moderate-intensity statins. Under one-fifth of patients with CVD and CVD + DM were prescribed high-intensity statins. Predictors of high-intensity statin prescriptions included male sex, having CVD or CVD + DM, increasing LDL-C, and LDL-C measured more recently (2012 to 2014 vs before 2012). In conclusion, a large proportion of patients at high CVD risk are not adequately treated with LLT. Despite often being considered a risk equivalent, patients with DM have substantially lower rates of LLT prescriptions and lesser controlled LDL-C than those with CVD or CVD + DM.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Oct","modification":"2024-10-15T19:44:45.848Z","creation":"2020-10-08T07:22:32Z"},"accession":"S-EPMC6744976","cross_references":{"pubmed":["31362878"],"doi":["10.1016/j.amjcard.2019.07.002"]}}