biostudies-literatureHao XScientific and Technological Research Project of Shanxi Province6723956https://www.ebi.ac.uk/biostudies/studies/S-EPMC6745139biostudies-literatureUnknown2019Xueniao capsule, one of the famous traditional Chinese medicine (TCM) formulas, has been proved to be effective for treating acute pyelonephritis (APN) in the clinic. However, the probable mechanisms are still unclear. This study was aimed at investigating the therapeutic effect and action mechanism of Xueniao capsule on acute pyelonephritis rats. Chemical analysis of Xueniao capsule and four different extracts was conducted by HPLC and GC-MS. 21 compounds were identified in the Xueniao capsule, and obvious chemical difference was also revealed among the different extracts by chemical analysis. Metabolomics, combined with bacteriological examination, traditional histopathology, and biochemical parameters, was used to evaluate the effects of Xueniao capsule and four different extracts. AfteEvidence-based complementary and alternative medicine : eCAMEffect of Xueniao Capsule on <i>Escherichia coli</i>-Induced Acute Pyelonephritis Rats by ¹H NMR-Based Metabolomic Approach.PMC67451392014ZD0203Ni YYao JYang YChen LHao XLiu CHe PfalseEffect of Xueniao Capsule on <i>Escherichia coli</i>-Induced Acute Pyelonephritis Rats by ¹H NMR-Based Metabolomic Approach.Xueniao capsule, one of the famous traditional Chinese medicine (TCM) formulas, has been proved to be effective for treating acute pyelonephritis (APN) in the clinic. However, the probable mechanisms are still unclear. This study was aimed at investigating the therapeutic effect and action mechanism of Xueniao capsule on acute pyelonephritis rats. Chemical analysis of Xueniao capsule and four different extracts was conducted by HPLC and GC-MS. 21 compounds were identified in the Xueniao capsule, and obvious chemical difference was also revealed among the different extracts by chemical analysis. Metabolomics, combined with bacteriological examination, traditional histopathology, and biochemical parameters, was used to evaluate the effects of Xueniao capsule and four different extracts. Afte2019-01-01T00:00:00Z20192025-04-22T06:14:31.334Z2019-10-11T07:05:33ZS-EPMC67451393156506310.1155/2019/6723956