{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bertholdt C"],"funding":["Regional Award of Clinical Research"],"pagination":["e030353"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6747665"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(9)"],"pubmed_abstract":["<h4>Introduction</h4>Knowledge about the mechanisms leading to the establishment of uteroplacental vascularisation is inadequate, and some of what has been thought to be known for decades has recently been challenged by showing that the intervillous space, the major area of maternal-fetal exchange, appears to be perfused by maternal blood at as early as 6 weeks of gestation. The vascular flow then seems relatively constant until 13 weeks when it appears to increase suddenly.<h4>Objectives</h4>The principal objective is to quantify the perfusion of the intervillous space by contrast-enhanced ultrasonography (CEUS) during the first-trimester at three different gestational ages (8, 11 and 13 weeks). The secondary objectives are to: (1) describe the indicators of vascularisation of the placent"],"journal":["BMJ open"],"pubmed_title":["Assessment of uteroplacental vascularisation in early first-trimester pregnancy with contrast-enhanced ultrasound and 3D power Doppler angiography: protocol for a prospective, cross-sectional, multicentre and non-randomised open study (\"HOPE Study\")."],"pmcid":["PMC6747665"],"funding_grant_id":["Regional Award of Clinical Research"],"pubmed_authors":["Hossu G","Cherifi A","Bertholdt C","Mellouki N","Morel O","Eszto ML","Tournier M"],"additional_accession":[]},"is_claimable":false,"name":"Assessment of uteroplacental vascularisation in early first-trimester pregnancy with contrast-enhanced ultrasound and 3D power Doppler angiography: protocol for a prospective, cross-sectional, multicentre and non-randomised open study (\"HOPE Study\").","description":"<h4>Introduction</h4>Knowledge about the mechanisms leading to the establishment of uteroplacental vascularisation is inadequate, and some of what has been thought to be known for decades has recently been challenged by showing that the intervillous space, the major area of maternal-fetal exchange, appears to be perfused by maternal blood at as early as 6 weeks of gestation. The vascular flow then seems relatively constant until 13 weeks when it appears to increase suddenly.<h4>Objectives</h4>The principal objective is to quantify the perfusion of the intervillous space by contrast-enhanced ultrasonography (CEUS) during the first-trimester at three different gestational ages (8, 11 and 13 weeks). The secondary objectives are to: (1) describe the indicators of vascularisation of the placent","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Sep","modification":"2026-05-03T18:42:59.874Z","creation":"2019-10-11T07:06:15Z"},"accession":"S-EPMC6747665","cross_references":{"pubmed":["31511289"],"doi":["10.1136/bmjopen-2019-030353"]}}