biostudies-literatureKim YHNIAID NIH HHSNCI NIH HHS1255-1257https://www.ebi.ac.uk/biostudies/studies/S-EPMC6748641biostudies-literatureUnknown48(7)We show the presence of lymphoid tissue-resident PLZF+ CD45RA+ RO+ CD4 T cells in humans. They express HLA-DR, granzyme B, and perforin and are low on CCR7 like terminally differentiated effector memory (Temra) cells and are likely generated from effector T cells (Te) or from central (Tcm) or effector (Tem) memory T (Tcm) cells during immune responses. Tn, Naïve T cells.European journal of immunologyPLZF-expressing CD4 T cells show the characteristics of terminally differentiated effector memory CD4 T cells in humans.PMC6748641R01 AI073677R01 AI073146U19 AI096113R01 AI111899P30 CA046592Kim YHZhu LLopez CChang CHPyaram KOhye RGGarcia JVGreen GEfalsePLZF-expressing CD4 T cells show the characteristics of terminally differentiated effector memory CD4 T cells in humans.We show the presence of lymphoid tissue-resident PLZF+ CD45RA+ RO+ CD4 T cells in humans. They express HLA-DR, granzyme B, and perforin and are low on CCR7 like terminally differentiated effector memory (Temra) cells and are likely generated from effector T cells (Te) or from central (Tcm) or effector (Tem) memory T (Tcm) cells during immune responses. Tn, Naïve T cells.2018-01-01T00:00:00Z2018 Jul2020-10-29T12:23:48Z2019-09-24T07:02:22ZS-EPMC67486412957280910.1002/eji.201747426