{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(1)"],"submitter":["Bloom M"],"funding":["Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada"],"pubmed_abstract":["The chordate gastrin/cholecystokinin and ecdysozoan sulfakinin (SK)-signaling systems are functionally and structurally homologous. In the present study, we isolated the cDNA sequences encoding the SK receptors in Rhodnius prolixus (Rhopr-SKR-1 and Rhopr-SKR-2). The Rhopr-SKRs have been functionally characterized and their intracellular signaling pathways analysed via a functional receptor assay. Both Rhopr-SKRs are exclusively activated via the two native R. prolixus sulfakinins, Rhopr-SK-1 and Rhopr-SK-2, but not via nonsulfated Rhopr-SK-1. The Rhopr-SKRs are each linked to the intracellular Ca<sup>2+</sup> second messenger pathway, and not to the cyclic AMP pathway. Spatial transcript expression analyses revealed that each Rhopr-SKR is predominantly expressed in the central nervous syst"],"journal":["Scientific reports"],"pagination":["13437"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6748952"],"repository":["biostudies-literature"],"pubmed_title":["Identification, Functional Characterization, and Pharmacological Analysis of Two Sulfakinin Receptors in the Medically-Important Insect Rhodnius prolixus."],"pmcid":["PMC6748952"],"pubmed_authors":["Orchard I","Bloom M","Lange AB"],"additional_accession":[]},"is_claimable":false,"name":"Identification, Functional Characterization, and Pharmacological Analysis of Two Sulfakinin Receptors in the Medically-Important Insect Rhodnius prolixus.","description":"The chordate gastrin/cholecystokinin and ecdysozoan sulfakinin (SK)-signaling systems are functionally and structurally homologous. In the present study, we isolated the cDNA sequences encoding the SK receptors in Rhodnius prolixus (Rhopr-SKR-1 and Rhopr-SKR-2). The Rhopr-SKRs have been functionally characterized and their intracellular signaling pathways analysed via a functional receptor assay. Both Rhopr-SKRs are exclusively activated via the two native R. prolixus sulfakinins, Rhopr-SK-1 and Rhopr-SK-2, but not via nonsulfated Rhopr-SK-1. The Rhopr-SKRs are each linked to the intracellular Ca<sup>2+</sup> second messenger pathway, and not to the cyclic AMP pathway. Spatial transcript expression analyses revealed that each Rhopr-SKR is predominantly expressed in the central nervous syst","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Sep","modification":"2026-05-07T12:35:32.435Z","creation":"2019-10-11T07:06:35Z"},"accession":"S-EPMC6748952","cross_references":{"pubmed":["31530854"],"doi":["10.1038/s41598-019-49790-x"]}}