{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(1)"],"submitter":["Freitas GP"],"pubmed_abstract":["Treatment of large bone defects is a challenging clinical situation that may be benefited from cell therapies based on regenerative medicine. This study was conducted to evaluate the effect of local injection of bone marrow-derived mesenchymal stromal cells (BM-MSCs) or adipose tissue-derived MSCs (AT-MSCs) on the regeneration of rat calvarial defects. BM-MSCs and AT-MSCs were characterized based on their expression of specific surface markers; cell viability was evaluated after injection with a 21-G needle. Defects measuring 5 mm that were created in rat calvaria were injected with BM-MSCs, AT-MSCs, or vehicle-phosphate-buffered saline (Control) 2 weeks post-defect creation. Cells were tracked by bioluminescence, and 4 weeks post-injection, the newly formed bone was evaluated by µCT, hist"],"journal":["Scientific reports"],"pagination":["13476"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6748998"],"repository":["biostudies-literature"],"pubmed_title":["Cell Therapy: Effect of Locally Injected Mesenchymal Stromal Cells Derived from Bone Marrow or Adipose Tissue on Bone Regeneration of Rat Calvarial Defects."],"pmcid":["PMC6748998"],"pubmed_authors":["Lopes HB","Freitas GP","Coelho PG","Souza LEB","Rosa AL","Souza ATP","Oliveira PGFP","Beloti MM","Almeida ALG"],"additional_accession":[]},"is_claimable":false,"name":"Cell Therapy: Effect of Locally Injected Mesenchymal Stromal Cells Derived from Bone Marrow or Adipose Tissue on Bone Regeneration of Rat Calvarial Defects.","description":"Treatment of large bone defects is a challenging clinical situation that may be benefited from cell therapies based on regenerative medicine. This study was conducted to evaluate the effect of local injection of bone marrow-derived mesenchymal stromal cells (BM-MSCs) or adipose tissue-derived MSCs (AT-MSCs) on the regeneration of rat calvarial defects. BM-MSCs and AT-MSCs were characterized based on their expression of specific surface markers; cell viability was evaluated after injection with a 21-G needle. Defects measuring 5 mm that were created in rat calvaria were injected with BM-MSCs, AT-MSCs, or vehicle-phosphate-buffered saline (Control) 2 weeks post-defect creation. Cells were tracked by bioluminescence, and 4 weeks post-injection, the newly formed bone was evaluated by µCT, hist","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Sep","modification":"2025-04-21T23:20:26.495Z","creation":"2019-10-11T07:06:37Z"},"accession":"S-EPMC6748998","cross_references":{"pubmed":["31530883"],"doi":["10.1038/s41598-019-50067-6"]}}