{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["22(18)"],"submitter":["Kizhatil K"],"pubmed_abstract":["Doublecortin is a cytoplasmic protein mutated in the neuronal migration disorder X-linked lissencephaly. This study describes a novel activity of doublecortin in recognition of the FIGQY-phosphotyrosine motif present in the cytoplasmic domain of the L1 cell adhesion molecule neurofascin. Phospho-FIGQY-neurofascin (186 kDa) coimmunoprecipitated with doublecortin from detergent extracts of embryonic brain membranes, and this doublecortin-phospho-FIGQY neurofascin complex was disassociated by a synthetic phospho-FIGQY neurofascin peptide but not by a dephospho-FIGQY peptide. Doublecortin specifically recognized the phospho-FIGQY tyrosine in the context of a synthetic phospho-FIGQY neurofascin peptide and in phospho-FIGQY neurofascin isolated from cells treated with pervanadate. Mutations of d"],"journal":["The Journal of neuroscience : the official journal of the Society for Neuroscience"],"pagination":["7948-58"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6758080"],"repository":["biostudies-literature"],"pubmed_title":["A new activity of doublecortin in recognition of the phospho-FIGQY tyrosine in the cytoplasmic domain of neurofascin."],"pmcid":["PMC6758080"],"pubmed_authors":["Kizhatil K","Bennett V","Sen A","Wu YX"],"additional_accession":[]},"is_claimable":false,"name":"A new activity of doublecortin in recognition of the phospho-FIGQY tyrosine in the cytoplasmic domain of neurofascin.","description":"Doublecortin is a cytoplasmic protein mutated in the neuronal migration disorder X-linked lissencephaly. This study describes a novel activity of doublecortin in recognition of the FIGQY-phosphotyrosine motif present in the cytoplasmic domain of the L1 cell adhesion molecule neurofascin. Phospho-FIGQY-neurofascin (186 kDa) coimmunoprecipitated with doublecortin from detergent extracts of embryonic brain membranes, and this doublecortin-phospho-FIGQY neurofascin complex was disassociated by a synthetic phospho-FIGQY neurofascin peptide but not by a dephospho-FIGQY peptide. Doublecortin specifically recognized the phospho-FIGQY tyrosine in the context of a synthetic phospho-FIGQY neurofascin peptide and in phospho-FIGQY neurofascin isolated from cells treated with pervanadate. Mutations of d","dates":{"release":"2002-01-01T00:00:00Z","publication":"2002 Sep","modification":"2025-04-26T00:04:13.403Z","creation":"2019-10-11T07:10:24Z"},"accession":"S-EPMC6758080","cross_references":{"pubmed":["12223548"],"doi":["10.1523/jneurosci.22-18-07948.2002","10.1523/JNEUROSCI.22-18-07948.2002"]}}