{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Su C"],"pubmed_abstract":["<b>Objective:</b> The aim of this study was to determine whether Si-Miao-Yong-An decoction (SMYAD) could ameliorate pressure overload-induced heart hypertrophy and its mechanisms. <b>Methods:</b> C57BL/6 mice were subjected to either sham or transverse aortic constriction (TAC) surgery to induce heart hypertrophy. SMYAD (14.85 g/kg/day, ig) or captopril (16.5 mg/kg/day, ig) was administered to the mice for 4 weeks. Cardiac function was evaluated based on echocardiography. Heart hypertrophy was detected using hematoxylin and eosin or wheat germ agglutinin staining. Protein expression of CD41, CD61, and P-selectin were measured with Western blot and immunohistochemistry. The expression levels of atrial natriuretic peptide, brain natriuretic peptide, β-myosin heavy chain, β-thromboglobulin, a"],"journal":["Frontiers in pharmacology"],"pagination":["990"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6759602"],"repository":["biostudies-literature"],"pubmed_title":["Si-Miao-Yong-An Decoction Protects Against Cardiac Hypertrophy and Dysfunction by Inhibiting Platelet Aggregation and Activation."],"pmcid":["PMC6759602"],"pubmed_authors":["Su C","Wang Q","Li S","Zhang H","Liu B","Wang W","Luo H","Chen X","Guo S","Li L","Yu X","Jiao W"],"additional_accession":[]},"is_claimable":false,"name":"Si-Miao-Yong-An Decoction Protects Against Cardiac Hypertrophy and Dysfunction by Inhibiting Platelet Aggregation and Activation.","description":"<b>Objective:</b> The aim of this study was to determine whether Si-Miao-Yong-An decoction (SMYAD) could ameliorate pressure overload-induced heart hypertrophy and its mechanisms. <b>Methods:</b> C57BL/6 mice were subjected to either sham or transverse aortic constriction (TAC) surgery to induce heart hypertrophy. SMYAD (14.85 g/kg/day, ig) or captopril (16.5 mg/kg/day, ig) was administered to the mice for 4 weeks. Cardiac function was evaluated based on echocardiography. Heart hypertrophy was detected using hematoxylin and eosin or wheat germ agglutinin staining. Protein expression of CD41, CD61, and P-selectin were measured with Western blot and immunohistochemistry. The expression levels of atrial natriuretic peptide, brain natriuretic peptide, β-myosin heavy chain, β-thromboglobulin, a","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2026-05-07T17:25:16.699Z","creation":"2019-10-30T08:17:26Z"},"accession":"S-EPMC6759602","cross_references":{"pubmed":["31619988"],"doi":["10.3389/fphar.2019.00990"]}}