biostudies-literatureQiao YNIA NIH HHSe013049https://www.ebi.ac.uk/biostudies/studies/S-EPMC6759892biostudies-literatureUnknown8(16)Background Cardiovascular disease (CVD) and fatigue commonly co-occur in older adults, yet the subjective nature of fatigue and its situational dependence leave the true magnitude of this association undefined. Methods and Results Six-hundred and twenty-five participants with no history of CVD (aged 68.1+12.0 years), from the Baltimore Longitudinal Study of Aging who underwent ≥2 clinic visits between 2007 and 2015 were classified according to sex-specific predicted 10-year CVD risk scores using the Framingham CVD risk score (Framingham) and the Pooled Cohort Equation at baseline. Perceived fatigability was assessed using the Borg rating of perceived exertion scale after a 5-minute treadmill walk (0.67 m/s, 0% grade). Linear models were used to assess the association between baseline CVD rJournal of the American Heart AssociationAssociation Between Cardiovascular Risk and Perceived Fatigability in Mid-to-Late Life.PMC6759892T32 AG000247P30 AG021334R21 AG053198Qiao YSimonsick EMFerrucci LWanigatunga AAUrbanek JKSchrack JAMartinez-Amezcua PfalseAssociation Between Cardiovascular Risk and Perceived Fatigability in Mid-to-Late Life.Background Cardiovascular disease (CVD) and fatigue commonly co-occur in older adults, yet the subjective nature of fatigue and its situational dependence leave the true magnitude of this association undefined. Methods and Results Six-hundred and twenty-five participants with no history of CVD (aged 68.1+12.0 years), from the Baltimore Longitudinal Study of Aging who underwent ≥2 clinic visits between 2007 and 2015 were classified according to sex-specific predicted 10-year CVD risk scores using the Framingham CVD risk score (Framingham) and the Pooled Cohort Equation at baseline. Perceived fatigability was assessed using the Borg rating of perceived exertion scale after a 5-minute treadmill walk (0.67 m/s, 0% grade). Linear models were used to assess the association between baseline CVD r2019-01-01T00:00:00Z2019 Aug2025-04-04T07:52:20.751Z2019-10-11T07:10:45ZS-EPMC67598923140920610.1161/JAHA.119.013049