{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(16)"],"submitter":["Mejia-Renteria H"],"pubmed_abstract":["Background Quantitative flow ratio (QFR), a novel functional angiography technique, computes fractional flow reserve (FFR) without pressure wires or adenosine. We investigated interindividual variations in the adenosine-induced hemodynamics during FFR assessment and their influence on QFR diagnostic performance. Methods and Results Patients with coronary stenoses who underwent intracoronary pressure and flow assessment were analyzed. Adenosine-induced hemodynamics during FFR measurement were determined by the percentage change in mean aortic pressure (%ΔPa) and the resistive reserve ratio (RRR). The diagnostic performance of QFR was evaluated and compared in each tertile of %ΔPa and RRR using FFR as reference. A total of 294 vessels (245 patients) were analyzed. Mean FFR was 0.80±0.11. Ind"],"journal":["Journal of the American Heart Association"],"pagination":["e012906"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6759899"],"repository":["biostudies-literature"],"pubmed_title":["Interindividual Variations in the Adenosine-Induced Hemodynamics During Fractional Flow Reserve Evaluation: Implications for the Use of Quantitative Flow Ratio in Assessing Intermediate Coronary Stenoses."],"pmcid":["PMC6759899"],"pubmed_authors":["Fernandez-Ortiz A","Lauri FM","Koo BK","Lee JM","McInerney A","de Waard GA","Mejia-Renteria H","Macaya C","van Royen N","Knaapen P","van der Hoeven NW","Escaned J"],"additional_accession":[]},"is_claimable":false,"name":"Interindividual Variations in the Adenosine-Induced Hemodynamics During Fractional Flow Reserve Evaluation: Implications for the Use of Quantitative Flow Ratio in Assessing Intermediate Coronary Stenoses.","description":"Background Quantitative flow ratio (QFR), a novel functional angiography technique, computes fractional flow reserve (FFR) without pressure wires or adenosine. We investigated interindividual variations in the adenosine-induced hemodynamics during FFR assessment and their influence on QFR diagnostic performance. Methods and Results Patients with coronary stenoses who underwent intracoronary pressure and flow assessment were analyzed. Adenosine-induced hemodynamics during FFR measurement were determined by the percentage change in mean aortic pressure (%ΔPa) and the resistive reserve ratio (RRR). The diagnostic performance of QFR was evaluated and compared in each tertile of %ΔPa and RRR using FFR as reference. A total of 294 vessels (245 patients) were analyzed. Mean FFR was 0.80±0.11. Ind","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Aug","modification":"2025-04-04T07:52:23.3Z","creation":"2019-10-11T07:10:46Z"},"accession":"S-EPMC6759899","cross_references":{"pubmed":["31394987"],"doi":["10.1161/JAHA.119.012906"]}}