{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Wang H"],"pubmed_abstract":["<b>Introduction:</b> Leukocyte immunoglobulin-like receptor A3 (<i>LILRA3</i>) belongs to the LILR family with unique feature of a 6.7-kb deletion variation among individuals. Frequencies of the 6.7-kb deletion vary widely across populations, but so far it has not been carefully investigated among Han Chinese subpopulations. Furthermore, we previously identified the non-deleted (functional) <i>LILRA3</i> as a novel genetic risk for multiple autoimmune diseases. The current study aimed to investigate (i) whether frequencies of the <i>LILRA3</i> 6.7-kb deletion differ within Han Chinese subpopulations and (ii) whether the functional <i>LILRA3</i> is a novel genetic risk for ankylosing spondylitis (AS). <b>Methods:</b> The <i>LILRA3</i> 6.7-kb deletion was genotyped in two independent cohorts"],"journal":["Frontiers in genetics"],"pagination":["869"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6760026"],"repository":["biostudies-literature"],"pubmed_title":["Frequencies of the <i>LILRA3</i> 6.7-kb Deletion Are Highly Differentiated Among Han Chinese Subpopulations and Involved in Ankylosing Spondylitis Predisposition."],"pmcid":["PMC6760026"],"pubmed_authors":["Lv J","Li Z","Guo J","Wang Q","Zhang X","Cai Y","Zhou G","Wang H","Wang Y","Ye H","Tang Y"],"additional_accession":[]},"is_claimable":false,"name":"Frequencies of the <i>LILRA3</i> 6.7-kb Deletion Are Highly Differentiated Among Han Chinese Subpopulations and Involved in Ankylosing Spondylitis Predisposition.","description":"<b>Introduction:</b> Leukocyte immunoglobulin-like receptor A3 (<i>LILRA3</i>) belongs to the LILR family with unique feature of a 6.7-kb deletion variation among individuals. Frequencies of the 6.7-kb deletion vary widely across populations, but so far it has not been carefully investigated among Han Chinese subpopulations. Furthermore, we previously identified the non-deleted (functional) <i>LILRA3</i> as a novel genetic risk for multiple autoimmune diseases. The current study aimed to investigate (i) whether frequencies of the <i>LILRA3</i> 6.7-kb deletion differ within Han Chinese subpopulations and (ii) whether the functional <i>LILRA3</i> is a novel genetic risk for ankylosing spondylitis (AS). <b>Methods:</b> The <i>LILRA3</i> 6.7-kb deletion was genotyped in two independent cohorts","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2026-05-04T19:01:55.946Z","creation":"2019-10-30T08:17:31Z"},"accession":"S-EPMC6760026","cross_references":{"pubmed":["31620171"],"doi":["10.3389/fgene.2019.00869"]}}