biostudies-literatureUnknown10Wang H<b>Introduction:</b> Leukocyte immunoglobulin-like receptor A3 (<i>LILRA3</i>) belongs to the LILR family with unique feature of a 6.7-kb deletion variation among individuals. Frequencies of the 6.7-kb deletion vary widely across populations, but so far it has not been carefully investigated among Han Chinese subpopulations. Furthermore, we previously identified the non-deleted (functional) <i>LILRA3</i> as a novel genetic risk for multiple autoimmune diseases. The current study aimed to investigate (i) whether frequencies of the <i>LILRA3</i> 6.7-kb deletion differ within Han Chinese subpopulations and (ii) whether the functional <i>LILRA3</i> is a novel genetic risk for ankylosing spondylitis (AS). <b>Methods:</b> The <i>LILRA3</i> 6.7-kb deletion was genotyped in two independent cohortsFrontiers in genetics869https://www.ebi.ac.uk/biostudies/studies/S-EPMC6760026biostudies-literatureFrequencies of the <i>LILRA3</i> 6.7-kb Deletion Are Highly Differentiated Among Han Chinese Subpopulations and Involved in Ankylosing Spondylitis Predisposition.PMC6760026Lv JLi ZGuo JWang QZhang XCai YZhou GWang HWang YYe HTang YfalseFrequencies of the <i>LILRA3</i> 6.7-kb Deletion Are Highly Differentiated Among Han Chinese Subpopulations and Involved in Ankylosing Spondylitis Predisposition.<b>Introduction:</b> Leukocyte immunoglobulin-like receptor A3 (<i>LILRA3</i>) belongs to the LILR family with unique feature of a 6.7-kb deletion variation among individuals. Frequencies of the 6.7-kb deletion vary widely across populations, but so far it has not been carefully investigated among Han Chinese subpopulations. Furthermore, we previously identified the non-deleted (functional) <i>LILRA3</i> as a novel genetic risk for multiple autoimmune diseases. The current study aimed to investigate (i) whether frequencies of the <i>LILRA3</i> 6.7-kb deletion differ within Han Chinese subpopulations and (ii) whether the functional <i>LILRA3</i> is a novel genetic risk for ankylosing spondylitis (AS). <b>Methods:</b> The <i>LILRA3</i> 6.7-kb deletion was genotyped in two independent cohorts2019-01-01T00:00:00Z20192026-05-04T19:01:55.946Z2019-10-30T08:17:31ZS-EPMC67600263162017110.3389/fgene.2019.00869