{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Santos LR"],"funding":["Swiss National Science Foundation"],"pagination":["1302-1315"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6760180"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(9)"],"pubmed_abstract":["<b><i>Background:</i></b> Several single-nucleotide polymorphisms (SNPs) are known to increase the risk of Hashimoto's thyroiditis (HT); such SNPs reside in thyroid-specific genes or in genes related to autoimmunity, inflammation, and/or cellular defense to stress. The transcription factor Nrf2, encoded by <i>NFE2L2</i>, is a master regulator of the cellular antioxidant response. This study aimed to evaluate the impact of genetic variation in <i>NFE2L2</i> on the risk of developing HT. <b><i>Methods:</i></b> In a case-control candidate gene association study, functional SNPs in the <i>NFE2L2</i> promoter (rs35652124, rs6706649, and rs6721961) were examined either as independent risk factors or in combination with a previously characterized HT risk allele (rs28665122) in the gene <i>SELENOS"],"journal":["Thyroid : official journal of the American Thyroid Association"],"pubmed_title":["Interaction of Genetic Variations in <i>NFE2L2</i> and <i>SELENOS</i> Modulates the Risk of Hashimoto's Thyroiditis."],"pmcid":["PMC6760180"],"funding_grant_id":["153062"],"pubmed_authors":["Habeos IG","Simoes MS","Ziros PG","Chartoumpekis DV","Sykiotis GP","Renaud CO","Bongiovanni M","Duraes C","Carvalho D","Soares P","Esteves C","Santos LR","Pestana A","Neves C"],"additional_accession":[]},"is_claimable":false,"name":"Interaction of Genetic Variations in <i>NFE2L2</i> and <i>SELENOS</i> Modulates the Risk of Hashimoto's Thyroiditis.","description":"<b><i>Background:</i></b> Several single-nucleotide polymorphisms (SNPs) are known to increase the risk of Hashimoto's thyroiditis (HT); such SNPs reside in thyroid-specific genes or in genes related to autoimmunity, inflammation, and/or cellular defense to stress. The transcription factor Nrf2, encoded by <i>NFE2L2</i>, is a master regulator of the cellular antioxidant response. This study aimed to evaluate the impact of genetic variation in <i>NFE2L2</i> on the risk of developing HT. <b><i>Methods:</i></b> In a case-control candidate gene association study, functional SNPs in the <i>NFE2L2</i> promoter (rs35652124, rs6706649, and rs6721961) were examined either as independent risk factors or in combination with a previously characterized HT risk allele (rs28665122) in the gene <i>SELENOS","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Sep","modification":"2026-05-04T19:02:02.814Z","creation":"2019-10-11T07:10:50Z"},"accession":"S-EPMC6760180","cross_references":{"pubmed":["31426718"],"doi":["10.1089/thy.2018.0480"]}}