biostudies-literatureSantos LRSwiss National Science Foundation1302-1315https://www.ebi.ac.uk/biostudies/studies/S-EPMC6760180biostudies-literatureUnknown29(9)<b><i>Background:</i></b> Several single-nucleotide polymorphisms (SNPs) are known to increase the risk of Hashimoto's thyroiditis (HT); such SNPs reside in thyroid-specific genes or in genes related to autoimmunity, inflammation, and/or cellular defense to stress. The transcription factor Nrf2, encoded by <i>NFE2L2</i>, is a master regulator of the cellular antioxidant response. This study aimed to evaluate the impact of genetic variation in <i>NFE2L2</i> on the risk of developing HT. <b><i>Methods:</i></b> In a case-control candidate gene association study, functional SNPs in the <i>NFE2L2</i> promoter (rs35652124, rs6706649, and rs6721961) were examined either as independent risk factors or in combination with a previously characterized HT risk allele (rs28665122) in the gene <i>SELENOSThyroid : official journal of the American Thyroid AssociationInteraction of Genetic Variations in <i>NFE2L2</i> and <i>SELENOS</i> Modulates the Risk of Hashimoto's Thyroiditis.PMC6760180153062Habeos IGSimoes MSZiros PGChartoumpekis DVSykiotis GPRenaud COBongiovanni MDuraes CCarvalho DSoares PEsteves CSantos LRPestana ANeves CfalseInteraction of Genetic Variations in <i>NFE2L2</i> and <i>SELENOS</i> Modulates the Risk of Hashimoto's Thyroiditis.<b><i>Background:</i></b> Several single-nucleotide polymorphisms (SNPs) are known to increase the risk of Hashimoto's thyroiditis (HT); such SNPs reside in thyroid-specific genes or in genes related to autoimmunity, inflammation, and/or cellular defense to stress. The transcription factor Nrf2, encoded by <i>NFE2L2</i>, is a master regulator of the cellular antioxidant response. This study aimed to evaluate the impact of genetic variation in <i>NFE2L2</i> on the risk of developing HT. <b><i>Methods:</i></b> In a case-control candidate gene association study, functional SNPs in the <i>NFE2L2</i> promoter (rs35652124, rs6706649, and rs6721961) were examined either as independent risk factors or in combination with a previously characterized HT risk allele (rs28665122) in the gene <i>SELENOS2019-01-01T00:00:00Z2019 Sep2026-05-04T19:02:02.814Z2019-10-11T07:10:50ZS-EPMC67601803142671810.1089/thy.2018.0480