{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Delay C"],"funding":["Australian Research Council"],"pagination":["4763-4774"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6760281"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["70(18)"],"pubmed_abstract":["CEPs (C-TERMINALLY ENCODED PEPTIDEs) inhibit Arabidopsis primary root growth by unknown mechanisms. We investigated how CEP3 levels control primary root growth. CEP3 peptide application decreased cell division, S-phase cell number, root meristematic cell number, and meristem zone (MZ) size in a dose- and CEP RECEPTOR1-dependent manner. Grafting showed that CEP3-dependent growth inhibition requires root and shoot CEPR1. CEP3 induced mitotic quiescence in MZ cells significantly faster than that induced by nutrient limitation alone. CEP3 also inhibited the restoration of S-phase to mitotically quiescence cells by nutrient resupply without quantitatively reducing TARGET OF RAPAMYCIN (TOR) kinase activity. In contrast, cep3-1 had an increased meristem size and S-phase cell number under nitrogen"],"journal":["Journal of experimental botany"],"pubmed_title":["CEP3 levels affect starvation-related growth responses of the primary root."],"pmcid":["PMC6760281"],"funding_grant_id":["DP150104250"],"pubmed_authors":["Xiong Y","Djordjevic MA","Imin N","Delay C","Wang Y","Tyagi S","Chapman K","Taleski M"],"additional_accession":[]},"is_claimable":false,"name":"CEP3 levels affect starvation-related growth responses of the primary root.","description":"CEPs (C-TERMINALLY ENCODED PEPTIDEs) inhibit Arabidopsis primary root growth by unknown mechanisms. We investigated how CEP3 levels control primary root growth. CEP3 peptide application decreased cell division, S-phase cell number, root meristematic cell number, and meristem zone (MZ) size in a dose- and CEP RECEPTOR1-dependent manner. Grafting showed that CEP3-dependent growth inhibition requires root and shoot CEPR1. CEP3 induced mitotic quiescence in MZ cells significantly faster than that induced by nutrient limitation alone. CEP3 also inhibited the restoration of S-phase to mitotically quiescence cells by nutrient resupply without quantitatively reducing TARGET OF RAPAMYCIN (TOR) kinase activity. In contrast, cep3-1 had an increased meristem size and S-phase cell number under nitrogen","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Sep","modification":"2025-04-04T07:10:43.719Z","creation":"2019-10-11T07:10:53Z"},"accession":"S-EPMC6760281","cross_references":{"pubmed":["31173100"],"doi":["10.1093/jxb/erz270"]}}