{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ruiz-Jarabo I"],"funding":["Ministerio de Agricultura y Pesca, Alimentación y Medio Ambiente","Ministerio de Economía, Industria y Competitividad, Gobierno de España","PADI Foundation"],"pagination":["1217"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6764463"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10"],"pubmed_abstract":["Glucocorticoids are pleiotropic steroid hormones mediating redistribution of energy. They induce breakdown of glycogen stores and consequent plasma hyperglycaemia after stressful situations. Glucocorticoid actions in most vertebrate species are exerted by cortisol and corticosterone. However, 1α-hydroxycorticosterone is the dominant corticosteroid hormone in elasmobranchs, though its effects as a glucocorticoid are unknown. Here we demonstrate, by using ultra-performance liquid chromatography coupled to tandem mass spectrometry for the quantification of 1α-hydroxycorticosterone in plasma of the elasmobranch Scyliorhinus canicula, the response of this hormone to an acute-stress situation and for the first time its glucocorticoid action in elasmobranchs. After an acute air-exposure challenge"],"journal":["Frontiers in physiology"],"pubmed_title":["Plasma 1α-Hydroxycorticosterone as Biomarker for Acute Stress in Catsharks (Scyliorhinus canicula)."],"pmcid":["PMC6764463"],"funding_grant_id":["SUREDEPAR","AGL2013-48835-C2-R"],"pubmed_authors":["Mancera JM","Jerez-Cepa I","Fernandez-Castro M","Ruiz-Jarabo I","Aerts J","Barragan-Mendez C","Sobrino I"],"additional_accession":[]},"is_claimable":false,"name":"Plasma 1α-Hydroxycorticosterone as Biomarker for Acute Stress in Catsharks (Scyliorhinus canicula).","description":"Glucocorticoids are pleiotropic steroid hormones mediating redistribution of energy. They induce breakdown of glycogen stores and consequent plasma hyperglycaemia after stressful situations. Glucocorticoid actions in most vertebrate species are exerted by cortisol and corticosterone. However, 1α-hydroxycorticosterone is the dominant corticosteroid hormone in elasmobranchs, though its effects as a glucocorticoid are unknown. Here we demonstrate, by using ultra-performance liquid chromatography coupled to tandem mass spectrometry for the quantification of 1α-hydroxycorticosterone in plasma of the elasmobranch Scyliorhinus canicula, the response of this hormone to an acute-stress situation and for the first time its glucocorticoid action in elasmobranchs. After an acute air-exposure challenge","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2025-04-22T19:24:43.956Z","creation":"2019-10-19T07:18:32Z"},"accession":"S-EPMC6764463","cross_references":{"pubmed":["31616315"],"doi":["10.3389/fphys.2019.01217"]}}