{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Boellaard WPA"],"funding":["Erasmus MC","Dutch Cancer Society","KWF Kankerbestrijding","Erasmus Medisch Centrum"],"pagination":["463-468"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6767197"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(4)"],"pubmed_abstract":["<h4>Background</h4>The microRNA-371a-3p (miR-371a-3p) has been reported to be an informative liquid biopsy (serum and plasma) molecular biomarker for both diagnosis and follow-up of patients with a malignant (testicular) germ cell tumor ((T)GCT). It is expressed in all histological cancer elements, with the exception of mature teratoma. However, normal testis, semen, and serum of males with a disrupted testicular integrity without a TGCT may contain miR-371a-3p levels above threshold, of which the cellular origin is unknown.<h4>Objectives</h4>Therefore, a series of relevant tissues (frozen and formalin-fixed paraffin-embedded (FFPE), when available) from the complete male urogenital tract (i.e., kidney to urethra and testis to urethra) and semen was investigated for miR-371a-3p levels usin"],"journal":["Andrology"],"pubmed_title":["Cellular origin of microRNA-371a-3p in healthy males based on systematic urogenital tract tissue evaluation."],"pmcid":["PMC6767197"],"funding_grant_id":["KWF 13‐6001","KWF 13-6001"],"pubmed_authors":["Gillis AJM","Stoop H","Dorssers LCJ","Looijenga LHJ","Boellaard WPA","van Agthoven T","Boormans JL","Dinkelman-Smit M","van Leenders GJLH"],"additional_accession":[]},"is_claimable":false,"name":"Cellular origin of microRNA-371a-3p in healthy males based on systematic urogenital tract tissue evaluation.","description":"<h4>Background</h4>The microRNA-371a-3p (miR-371a-3p) has been reported to be an informative liquid biopsy (serum and plasma) molecular biomarker for both diagnosis and follow-up of patients with a malignant (testicular) germ cell tumor ((T)GCT). It is expressed in all histological cancer elements, with the exception of mature teratoma. However, normal testis, semen, and serum of males with a disrupted testicular integrity without a TGCT may contain miR-371a-3p levels above threshold, of which the cellular origin is unknown.<h4>Objectives</h4>Therefore, a series of relevant tissues (frozen and formalin-fixed paraffin-embedded (FFPE), when available) from the complete male urogenital tract (i.e., kidney to urethra and testis to urethra) and semen was investigated for miR-371a-3p levels usin","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jul","modification":"2025-04-18T14:06:55.388Z","creation":"2019-10-11T07:13:08Z"},"accession":"S-EPMC6767197","cross_references":{"pubmed":["30786164"],"doi":["10.1111/andr.12595"]}}