{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Elsayed SM"],"funding":["Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg"],"pagination":["E3371"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6767307"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(18)"],"pubmed_abstract":["This study presents a comparison of two types of bifunctional structured surface that were made from the same polymer -- an antimicrobial polycation (a synthetic mimic of an antimicrobial peptide, SMAMP) and a protein-repellent polyzwitterion (poly(sulfobetaines), PSB). The first type of bifunctional surface was fabricated by a colloidal lithography (CL) based process where the two polymers were immobilized sequentially onto pre-structured surfaces with a chemical contrast (gold on silicon). This enabled site-selective covalent attachment. The CL materials had a spacing ranging from 200 nm to 2 µm. The second type of structured surface (spacing: 1 - 8.5 µm) was fabricated using a microcontact printing (µCP) process where SMAMP patches were printed onto a PSB network, so that 3D surface fea"],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Bifunctional Bioactive Polymer Surfaces with Micrometer and Submicrometer-sized Structure: The Effects of Structure Spacing and Elastic Modulus on Bioactivity."],"pmcid":["PMC6767307"],"funding_grant_id":["GenMik II Graduate School"],"pubmed_authors":["Elsayed SM","Eickenscheidt A","Widyaya VT","Lienkamp K","2,","Shafi Y"],"additional_accession":[]},"is_claimable":false,"name":"Bifunctional Bioactive Polymer Surfaces with Micrometer and Submicrometer-sized Structure: The Effects of Structure Spacing and Elastic Modulus on Bioactivity.","description":"This study presents a comparison of two types of bifunctional structured surface that were made from the same polymer -- an antimicrobial polycation (a synthetic mimic of an antimicrobial peptide, SMAMP) and a protein-repellent polyzwitterion (poly(sulfobetaines), PSB). The first type of bifunctional surface was fabricated by a colloidal lithography (CL) based process where the two polymers were immobilized sequentially onto pre-structured surfaces with a chemical contrast (gold on silicon). This enabled site-selective covalent attachment. The CL materials had a spacing ranging from 200 nm to 2 µm. The second type of structured surface (spacing: 1 - 8.5 µm) was fabricated using a microcontact printing (µCP) process where SMAMP patches were printed onto a PSB network, so that 3D surface fea","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Sep","modification":"2026-05-07T10:29:22.366Z","creation":"2019-10-11T07:13:10Z"},"accession":"S-EPMC6767307","cross_references":{"pubmed":["31527527"],"doi":["10.3390/molecules24183371"]}}