{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["21(8)"],"submitter":["Spanopoulos D"],"funding":["Boehringer Ingelheim","Boehringer Ingelheim Ltd","Eli Lilly and Company"],"pubmed_abstract":["<h4>Aim</h4>To characterize the longitudinal variability of estimated glomerular filtration rate (eGFR) in people with type 2 diabetes mellitus (T2DM), including variation between categories and individuals.<h4>Methods</h4>People with T2DM and sufficient recorded serum creatinine measurements were identified from the Clinical Practice Research Datalink (T2DM diagnosis from 1 January 2009 to 1 January 2011 with 5 years follow-up); eGFR was calculated using the CKD-EPI equation.<h4>Results</h4>In total, 7766 individuals were included; 32.8%, 50.2%, 12.4%, 4.0% and 0.6% were in glomerular filtration rate (GFR) categories G1, G2, G3a, G3b and G4, respectively. Overall, eGFR decreased by 0.44 mL/min/1.73 m<sup>2</sup> per year; eGFR increased by 0.80 mL/min/1.73 m<sup>2</sup> between index and "],"journal":["Diabetes, obesity & metabolism"],"pagination":["1817-1823"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6767485"],"repository":["biostudies-literature"],"pubmed_title":["Temporal variation of renal function in people with type 2 diabetes mellitus: A retrospective UK clinical practice research datalink cohort study."],"pmcid":["PMC6767485"],"pubmed_authors":["Barrett B","Busse M","Okhai H","Tebboth A","Spanopoulos D","Webb J","Zaccardi F","Khunti K"],"additional_accession":[]},"is_claimable":false,"name":"Temporal variation of renal function in people with type 2 diabetes mellitus: A retrospective UK clinical practice research datalink cohort study.","description":"<h4>Aim</h4>To characterize the longitudinal variability of estimated glomerular filtration rate (eGFR) in people with type 2 diabetes mellitus (T2DM), including variation between categories and individuals.<h4>Methods</h4>People with T2DM and sufficient recorded serum creatinine measurements were identified from the Clinical Practice Research Datalink (T2DM diagnosis from 1 January 2009 to 1 January 2011 with 5 years follow-up); eGFR was calculated using the CKD-EPI equation.<h4>Results</h4>In total, 7766 individuals were included; 32.8%, 50.2%, 12.4%, 4.0% and 0.6% were in glomerular filtration rate (GFR) categories G1, G2, G3a, G3b and G4, respectively. Overall, eGFR decreased by 0.44 mL/min/1.73 m<sup>2</sup> per year; eGFR increased by 0.80 mL/min/1.73 m<sup>2</sup> between index and ","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Aug","modification":"2025-04-18T17:11:59.797Z","creation":"2019-10-11T07:13:17Z"},"accession":"S-EPMC6767485","cross_references":{"pubmed":["30941882"],"doi":["10.1111/dom.13734"]}}