biostudies-literatureUnknown21(8)Spanopoulos DBoehringer IngelheimBoehringer Ingelheim LtdEli Lilly and Company<h4>Aim</h4>To characterize the longitudinal variability of estimated glomerular filtration rate (eGFR) in people with type 2 diabetes mellitus (T2DM), including variation between categories and individuals.<h4>Methods</h4>People with T2DM and sufficient recorded serum creatinine measurements were identified from the Clinical Practice Research Datalink (T2DM diagnosis from 1 January 2009 to 1 January 2011 with 5 years follow-up); eGFR was calculated using the CKD-EPI equation.<h4>Results</h4>In total, 7766 individuals were included; 32.8%, 50.2%, 12.4%, 4.0% and 0.6% were in glomerular filtration rate (GFR) categories G1, G2, G3a, G3b and G4, respectively. Overall, eGFR decreased by 0.44 mL/min/1.73 m² per year; eGFR increased by 0.80 mL/min/1.73 m² between index and Diabetes, obesity & metabolism1817-1823https://www.ebi.ac.uk/biostudies/studies/S-EPMC6767485biostudies-literatureTemporal variation of renal function in people with type 2 diabetes mellitus: A retrospective UK clinical practice research datalink cohort study.PMC6767485Barrett BBusse MOkhai HTebboth ASpanopoulos DWebb JZaccardi FKhunti KfalseTemporal variation of renal function in people with type 2 diabetes mellitus: A retrospective UK clinical practice research datalink cohort study.<h4>Aim</h4>To characterize the longitudinal variability of estimated glomerular filtration rate (eGFR) in people with type 2 diabetes mellitus (T2DM), including variation between categories and individuals.<h4>Methods</h4>People with T2DM and sufficient recorded serum creatinine measurements were identified from the Clinical Practice Research Datalink (T2DM diagnosis from 1 January 2009 to 1 January 2011 with 5 years follow-up); eGFR was calculated using the CKD-EPI equation.<h4>Results</h4>In total, 7766 individuals were included; 32.8%, 50.2%, 12.4%, 4.0% and 0.6% were in glomerular filtration rate (GFR) categories G1, G2, G3a, G3b and G4, respectively. Overall, eGFR decreased by 0.44 mL/min/1.73 m² per year; eGFR increased by 0.80 mL/min/1.73 m² between index and 2019-01-01T00:00:00Z2019 Aug2025-04-18T17:11:59.797Z2019-10-11T07:13:17ZS-EPMC67674853094188210.1111/dom.13734