{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tan GW"],"funding":["Ministry of Health Malaysia"],"pagination":["2260-2266"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6767762"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["145(8)"],"pubmed_abstract":["Nasopharyngeal carcinoma (NPC) is an epithelial cancer of the nasopharynx which is highly associated with Epstein-Barr virus (EBV). Worldwide, most of the top 20 countries with the highest incidence and mortality rates of NPC are low- and middle-income countries. Many studies had demonstrated that EBV could be detected in the tissue, serum and plasma of NPC patients. In this study, we explored the potential of assays based on non-invasive nasal washings (NW) as a diagnostic and prognostic tool for NPC. A total of 128 patients were evaluated for NW EBV DNA loads and a subset of these samples were also tested for 27 EBV and human miRNAs shortlisted from literature. EBV DNA and seven miRNAs showed area under the receiver operating characteristic curve (AUC) values of more than 0.7, suggestive"],"journal":["International journal of cancer"],"pubmed_title":["A novel and non-invasive approach utilising nasal washings for the detection of nasopharyngeal carcinoma."],"pmcid":["PMC6767762"],"funding_grant_id":["NMRR-11-597-9667"],"pubmed_authors":["Tan LP","Sivanesan VM","Hasbullah HH","Abdul Rahman FI","Hassan F","Ng CC","Tan GW","Khoo AS"],"additional_accession":[]},"is_claimable":false,"name":"A novel and non-invasive approach utilising nasal washings for the detection of nasopharyngeal carcinoma.","description":"Nasopharyngeal carcinoma (NPC) is an epithelial cancer of the nasopharynx which is highly associated with Epstein-Barr virus (EBV). Worldwide, most of the top 20 countries with the highest incidence and mortality rates of NPC are low- and middle-income countries. Many studies had demonstrated that EBV could be detected in the tissue, serum and plasma of NPC patients. In this study, we explored the potential of assays based on non-invasive nasal washings (NW) as a diagnostic and prognostic tool for NPC. A total of 128 patients were evaluated for NW EBV DNA loads and a subset of these samples were also tested for 27 EBV and human miRNAs shortlisted from literature. EBV DNA and seven miRNAs showed area under the receiver operating characteristic curve (AUC) values of more than 0.7, suggestive","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Oct","modification":"2026-05-03T19:15:39.645Z","creation":"2019-10-11T07:13:27Z"},"accession":"S-EPMC6767762","cross_references":{"pubmed":["30698824"],"doi":["10.1002/ijc.32173"]}}