biostudies-literatureEsposito RMinistero dell’Istruzione, dell’Università e della RicercaNovo Nordisk Fonden1094https://www.ebi.ac.uk/biostudies/studies/S-EPMC6769077biostudies-literatureUnknown10Purpose: Gender differences exist in the prevalence of asthma and allergic diseases, partially due to the effects of sex hormones on the development of allergic manifestations. Women, compared with men, are more prone to suffer allergic asthma, experience difficulties in controlling asthma symptoms, and show adverse responses to drugs. However, there are knowledge gaps on the effectiveness of anti-leukotrienes drugs on lung function, symptoms, and pulmonary and systemic inflammation in adult asthmatic women compared with men. We conducted a prospective cohort study to characterize the effectiveness of an anti-leukotrienes drug, montelukast (MS), in asthmatic adult women and men. Methods: Twenty-one asthmatic subjects (11 women and 10 men), who were on low-dose inhaled corticosteroids (ICS)Frontiers in pharmacologyMontelukast Improves Symptoms and Lung Function in Asthmatic Women Compared With Men.PMC6769077NFF15SA0018404Giannattasio DPolverino FFerrigno FEsposito RFalciani MPolverino MSessa MRoviezzo FBerrino LSpaziano GD'Agostino BLiparulo ARossi AfalseMontelukast Improves Symptoms and Lung Function in Asthmatic Women Compared With Men.Purpose: Gender differences exist in the prevalence of asthma and allergic diseases, partially due to the effects of sex hormones on the development of allergic manifestations. Women, compared with men, are more prone to suffer allergic asthma, experience difficulties in controlling asthma symptoms, and show adverse responses to drugs. However, there are knowledge gaps on the effectiveness of anti-leukotrienes drugs on lung function, symptoms, and pulmonary and systemic inflammation in adult asthmatic women compared with men. We conducted a prospective cohort study to characterize the effectiveness of an anti-leukotrienes drug, montelukast (MS), in asthmatic adult women and men. Methods: Twenty-one asthmatic subjects (11 women and 10 men), who were on low-dose inhaled corticosteroids (ICS)2019-01-01T00:00:00Z20192025-04-21T23:28:11.899Z2025-04-05T19:06:01.674ZS-EPMC67690773161179010.3389/fphar.2019.01094