{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yu D"],"funding":["National Natural Science Foundation of China"],"pagination":["1251-1264"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6771797"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(8)"],"pubmed_abstract":["Liver transplantation (LT) is currently considered an important method in treating hepatocellular carcinoma (HCC) and an alternative treatment for other liver malignancies. Here, we demonstrated that the graft-versus-tumor (GVT) effect exists in allogeneic liver transplantation (allo LT). Recipient-derived T cells played a critical role in the GVT process of allo LT, as demonstrated by extensive infiltration and significant activation of recipient T cells in the tumor after surgery. Moreover, this process was related to donor-derived T/B cells by improving the immune microenvironment in the tumor, as demonstrated by elevated levels of interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), interleukin-2 (IL-2), IL-6, IL-16, chemokine (C-X-C motif) ligand 10 (CXCL10), and CXCL11 and decrease"],"journal":["Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society"],"pubmed_title":["Graft-Versus-Tumor Effect in Major Histocompatibility Complex-Mismatched Mouse Liver Transplantation."],"pmcid":["PMC6771797"],"funding_grant_id":["81572975","81372626"],"pubmed_authors":["Li H","Zhou L","Zhang J","Zhang Y","Tian Y","Zheng S","Yu D","Yan S","Wu T","Wang Y","Cui C","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"Graft-Versus-Tumor Effect in Major Histocompatibility Complex-Mismatched Mouse Liver Transplantation.","description":"Liver transplantation (LT) is currently considered an important method in treating hepatocellular carcinoma (HCC) and an alternative treatment for other liver malignancies. Here, we demonstrated that the graft-versus-tumor (GVT) effect exists in allogeneic liver transplantation (allo LT). Recipient-derived T cells played a critical role in the GVT process of allo LT, as demonstrated by extensive infiltration and significant activation of recipient T cells in the tumor after surgery. Moreover, this process was related to donor-derived T/B cells by improving the immune microenvironment in the tumor, as demonstrated by elevated levels of interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), interleukin-2 (IL-2), IL-6, IL-16, chemokine (C-X-C motif) ligand 10 (CXCL10), and CXCL11 and decrease","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Aug","modification":"2025-04-04T08:26:13.945Z","creation":"2019-10-16T07:05:40Z"},"accession":"S-EPMC6771797","cross_references":{"pubmed":["31152624"],"doi":["10.1002/lt.25574"]}}