biostudies-literatureGoedee HSPrinses Beatrix Spierfonds263-270https://www.ebi.ac.uk/biostudies/studies/S-EPMC6771847biostudies-literatureUnknown60(3)INTRODUCTION:We assessed the specific sonographic pattern of structural nerve abnormalities in immunoglobulin M (IgM) neuropathy and disease controls. METHODS:We enrolled 106 incident patients-32 patients with IgM neuropathy, 42 treatment-naive patients with chronic inflammatory demyelinating polyneuropathy, and 32 patients with axonal neuropathies. All patients underwent standardized ancillary testing in addition to standardized sonography of the brachial plexus and the large arm and leg nerves bilaterally. RESULTS:We found widespread nerve enlargement in IgM neuropathy and chronic inflammatory demyelinating polyneuropathy (CIDP), with specific enlargement of brachial plexus and proximal segments of median nerve but not in axonal disease controls (P < .001). Sonographic nerve hypertrophy Muscle & nerveNeuropathy associated with immunoglobulin M monoclonal gammopathy: A combined sonographic and nerve conduction study.PMC6771847W.OR14‐08Goedee HSVrancken AFJEvan den Berg LHvan Asseldonk JHFranssen HVisser LHNikolakopoulos SNotermans NCvan der Pol WLfalseNeuropathy associated with immunoglobulin M monoclonal gammopathy: A combined sonographic and nerve conduction study.INTRODUCTION:We assessed the specific sonographic pattern of structural nerve abnormalities in immunoglobulin M (IgM) neuropathy and disease controls. METHODS:We enrolled 106 incident patients-32 patients with IgM neuropathy, 42 treatment-naive patients with chronic inflammatory demyelinating polyneuropathy, and 32 patients with axonal neuropathies. All patients underwent standardized ancillary testing in addition to standardized sonography of the brachial plexus and the large arm and leg nerves bilaterally. RESULTS:We found widespread nerve enlargement in IgM neuropathy and chronic inflammatory demyelinating polyneuropathy (CIDP), with specific enlargement of brachial plexus and proximal segments of median nerve but not in axonal disease controls (P < .001). Sonographic nerve hypertrophy 2019-01-01T00:00:00Z2019 Sep2025-04-04T08:26:24.206Z2019-10-16T07:05:44ZS-EPMC67718473126924310.1002/mus.26626