biostudies-literatureUnknown58(37)Bai STReported is an iridium catalyst for ortho-selective C-H borylation of challenging secondary aromatic amide substrates, and the regioselectivity is controlled by hydrogen-bond interactions. The BAIPy-Ir catalyst forms three hydrogen bonds with the substrate during the crucial activation step, and allows ortho-C-H borylation with high selectivity. The catalyst displays unprecedented ortho selectivities for a wide variety of substrates that differ in electronic and steric properties, and the catalyst tolerates various functional groups. The regioselective C-H borylation catalyst is readily accessible and converts substrates on gram scale with high selectivity and conversion.Angewandte Chemie (International ed. in English)13039-13043https://www.ebi.ac.uk/biostudies/studies/S-EPMC6772079biostudies-literatureHydrogen Bond Directed ortho-Selective C-H Borylation of Secondary Aromatic Amides.PMC6772079Bai STBheeter CBReek JNHfalseHydrogen Bond Directed ortho-Selective C-H Borylation of Secondary Aromatic Amides.Reported is an iridium catalyst for ortho-selective C-H borylation of challenging secondary aromatic amide substrates, and the regioselectivity is controlled by hydrogen-bond interactions. The BAIPy-Ir catalyst forms three hydrogen bonds with the substrate during the crucial activation step, and allows ortho-C-H borylation with high selectivity. The catalyst displays unprecedented ortho selectivities for a wide variety of substrates that differ in electronic and steric properties, and the catalyst tolerates various functional groups. The regioselective C-H borylation catalyst is readily accessible and converts substrates on gram scale with high selectivity and conversion.2019-01-01T00:00:00Z2019 Sep2025-04-04T08:26:47.327Z2019-10-16T07:05:54ZS-EPMC67720793123798810.1002/anie.201907366