biostudies-literaturePalma AAssociazione Italiana per la Ricerca sul CancroEuropean Research Council1216https://www.ebi.ac.uk/biostudies/studies/S-EPMC6776608biostudies-literatureUnknown10Muscle regeneration is a complex process governed by the interplay between several muscle-resident mononuclear cell populations. Following acute or chronic damage these cell populations are activated, communicate via cell-cell interactions and/or paracrine signals, influencing fate decisions via the activation or repression of internal signaling cascades. These are highly dynamic processes, occurring with distinct temporal and spatial kinetics. The main challenge toward a system level description of the muscle regeneration process is the integration of this plethora of inter- and intra-cellular interactions. We integrated the information on muscle regeneration in a web portal. The scientific content annotated in this portal is organized into two information layers representing relationshipFrontiers in physiologyMyo-REG: A Portal for Signaling Interactions in Muscle Regeneration.PMC6776608322749Giuliani GCesareni GFerrentino FFuoco CSacco FPalma AZuccotti AIannuccelli MReggio ALicata LVumbaca SCastagnoli LPaoluzi SMicarelli EPerfetto LPetrilli LLGargioli CCerquone Perpetuini ARosina MfalseMyo-REG: A Portal for Signaling Interactions in Muscle Regeneration.Muscle regeneration is a complex process governed by the interplay between several muscle-resident mononuclear cell populations. Following acute or chronic damage these cell populations are activated, communicate via cell-cell interactions and/or paracrine signals, influencing fate decisions via the activation or repression of internal signaling cascades. These are highly dynamic processes, occurring with distinct temporal and spatial kinetics. The main challenge toward a system level description of the muscle regeneration process is the integration of this plethora of inter- and intra-cellular interactions. We integrated the information on muscle regeneration in a web portal. The scientific content annotated in this portal is organized into two information layers representing relationship2019-01-01T00:00:00Z20192025-04-04T08:29:54.494Z2019-10-18T07:02:58ZS-EPMC67766083161180810.3389/fphys.2019.01216