{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rivera-Chavez J"],"funding":["NCCIH NIH HHS","National Cancer Institute","NCI NIH HHS"],"pagination":["594-597"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6785197"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["60(8)"],"pubmed_abstract":["A new 8,8'-binaphthopyranone (mycopyranone, <b>1</b>) was isolated from a solid fermentation of <i>Phialemoniopsis</i> sp. (fungal strain MSX61662), and the structure was elucidated via analysis of the NMR and HRESIMS data. The axial chirality of <b>1</b> was determined to be <i>M</i> by ECD. The central chirality at C-4/C-4' was assigned through a modified Mosher's method, while the absolute configuration at C-3/C-3' was deduced based on analysis of the <sup>3</sup> <i>J</i> <sub>H-3-H-4</sub> values and NOESY correlations. Compound <b>1</b> was evaluated for its antimicrobial properties against <i>Staphylococcus aureus</i> SA1199 and a clinically relevant methicillin-resistant <i>S. aureus</i> strain (MRSA USA300 LAC strain AH1263). Compound <b>1</b> inhibited the growth of both strains "],"journal":["Tetrahedron letters"],"pubmed_title":["Mycopyranone: a 8,8'-binaphthopyranone with potent anti-MRSA activity from the fungus <i>Phialemoniopsis</i> sp."],"pmcid":["PMC6785197"],"funding_grant_id":["P01 CA125066","T32 AT008938"],"pubmed_authors":["Cech NB","Pearce CJ","Garcia-Salazar JJ","Raja HA","Oberlies NH","Rivera-Chavez J","Caesar L"],"additional_accession":[]},"is_claimable":false,"name":"Mycopyranone: a 8,8'-binaphthopyranone with potent anti-MRSA activity from the fungus <i>Phialemoniopsis</i> sp.","description":"A new 8,8'-binaphthopyranone (mycopyranone, <b>1</b>) was isolated from a solid fermentation of <i>Phialemoniopsis</i> sp. (fungal strain MSX61662), and the structure was elucidated via analysis of the NMR and HRESIMS data. The axial chirality of <b>1</b> was determined to be <i>M</i> by ECD. The central chirality at C-4/C-4' was assigned through a modified Mosher's method, while the absolute configuration at C-3/C-3' was deduced based on analysis of the <sup>3</sup> <i>J</i> <sub>H-3-H-4</sub> values and NOESY correlations. Compound <b>1</b> was evaluated for its antimicrobial properties against <i>Staphylococcus aureus</i> SA1199 and a clinically relevant methicillin-resistant <i>S. aureus</i> strain (MRSA USA300 LAC strain AH1263). Compound <b>1</b> inhibited the growth of both strains ","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Feb","modification":"2026-04-29T03:43:44.854Z","creation":"2020-05-22T10:35:48Z"},"accession":"S-EPMC6785197","cross_references":{"pubmed":["31598014"],"doi":["10.1016/j.tetlet.2019.01.029"]}}