{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rapp TL"],"funding":["National Institute of General Medical Sciences","NIGMS NIH HHS","National Science Foundation"],"pagination":["4942-4947"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6785243"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(9)"],"pubmed_abstract":["Photoresponsive materials afford spatiotemporal control over desirable physical, chemical and biological properties. For advanced applications, there is need for molecular phototriggers that are readily incorporated within larger structures, and spatially-sequentially addressable with different wavelengths of visble light, enabling multiplexing. Here we describe spectrally tunable (λ<sub>max</sub> = 420-530 nm) ruthenium polypyridyl complexes functionalized with two photolabile nitrile ligands that present terminal alkynes for subsequent crosslinking reactions, including hydrogel formation. Two Ru crosslinkers were incorporated within a PEG-hydrogel matrix, and sequentially degraded by irradiation with 592 nm and 410 nm light."],"journal":["RSC advances"],"pubmed_title":["Designing Photolabile Ruthenium Polypyridyl Crosslinkers for Hydrogel Formation and Multiplexed, Visible-light Degradation."],"pmcid":["PMC6785243"],"funding_grant_id":["DMR-1720530","R01 GM-083030","R01 GM083030","R35 GM131907"],"pubmed_authors":["Dmochowski IJ","Delessio MA","Rapp TL","Wang Y","Gau MR"],"additional_accession":[]},"is_claimable":false,"name":"Designing Photolabile Ruthenium Polypyridyl Crosslinkers for Hydrogel Formation and Multiplexed, Visible-light Degradation.","description":"Photoresponsive materials afford spatiotemporal control over desirable physical, chemical and biological properties. For advanced applications, there is need for molecular phototriggers that are readily incorporated within larger structures, and spatially-sequentially addressable with different wavelengths of visble light, enabling multiplexing. Here we describe spectrally tunable (λ<sub>max</sub> = 420-530 nm) ruthenium polypyridyl complexes functionalized with two photolabile nitrile ligands that present terminal alkynes for subsequent crosslinking reactions, including hydrogel formation. Two Ru crosslinkers were incorporated within a PEG-hydrogel matrix, and sequentially degraded by irradiation with 592 nm and 410 nm light.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2024-12-03T17:39:16.681Z","creation":"2020-10-29T10:38:33Z"},"accession":"S-EPMC6785243","cross_references":{"pubmed":["31598214"],"doi":["10.1039/C8RA09764J"]}}