{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Madhi SA"],"funding":["Bill &amp; Melinda Gates Foundation"],"pagination":["S342-S350"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6785671"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["69(Suppl 4)"],"pubmed_abstract":["<h4>Background</h4>Despite approximately 2.6 million stillbirths occurring annually, there is a paucity of systematic biological investigation and consequently knowledge on the causes of these deaths in low- and middle-income countries (LMICs). We investigated the utility of minimally invasive tissue sampling (MITS), placental examination, and clinical history, in attributing the causes of stillbirth in a South African LMIC setting.<h4>Methods</h4>This prospective, observational pilot study undertook sampling of brain, lung, and liver tissue using core biopsy needles, blood and cerebrospinal fluid collection, and placental examination. Testing included microbial culture and/or molecular testing and tissue histological examination. The cause of death was determined for each case by an inter"],"journal":["Clinical infectious diseases : an official publication of the Infectious Diseases Society of America"],"pubmed_title":["An Observational Pilot Study Evaluating the Utility of Minimally Invasive Tissue Sampling to Determine the Cause of Stillbirths in South African Women."],"pmcid":["PMC6785671"],"funding_grant_id":["OPP1101764"],"pubmed_authors":["Martines RB","Mathunjwa A","Solomon F","Nzenze S","Bassat Q","Cutland C","Baillie V","Ritter JM","Wadula J","Zaki SR","Adam Y","Chawana R","Raghunathan PL","Ordi J","Madhi SA","Izu A","Blau DM","Pathirana J","Breiman RF","Hale M","Johnstone S"],"additional_accession":[]},"is_claimable":false,"name":"An Observational Pilot Study Evaluating the Utility of Minimally Invasive Tissue Sampling to Determine the Cause of Stillbirths in South African Women.","description":"<h4>Background</h4>Despite approximately 2.6 million stillbirths occurring annually, there is a paucity of systematic biological investigation and consequently knowledge on the causes of these deaths in low- and middle-income countries (LMICs). We investigated the utility of minimally invasive tissue sampling (MITS), placental examination, and clinical history, in attributing the causes of stillbirth in a South African LMIC setting.<h4>Methods</h4>This prospective, observational pilot study undertook sampling of brain, lung, and liver tissue using core biopsy needles, blood and cerebrospinal fluid collection, and placental examination. Testing included microbial culture and/or molecular testing and tissue histological examination. The cause of death was determined for each case by an inter","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Oct","modification":"2026-04-14T09:21:50.787Z","creation":"2019-10-19T07:20:31Z"},"accession":"S-EPMC6785671","cross_references":{"pubmed":["31598656"],"doi":["10.1093/cid/ciz573"]}}