biostudies-literatureWhitaker JBritish Heart FoundationMedical Research CouncilNHLBI NIH HHSNational Institute for Health Research (NIHR)Health Innovation Challenge FundWellcome TrustEngineering and Physical Sciences Research Council62https://www.ebi.ac.uk/biostudies/studies/S-EPMC6785908biostudies-literatureUnknown21(1)<h4>Background</h4>Ex-vivo cardiovascular magnetic resonance (CMR) imaging has played an important role in the validation of in-vivo CMR characterization of pathological processes. However, comparison between in-vivo and ex-vivo imaging remains challenging due to shape changes occurring between the two states, which may be non-uniform across the diseased heart. A novel two-step process to facilitate registration between ex-vivo and in-vivo CMR was developed and evaluated in a porcine model of chronic myocardial infarction (MI).<h4>Methods</h4>Seven weeks after ischemia-reperfusion MI, 12 swine underwent in-vivo CMR imaging with late gadolinium enhancement followed by ex-vivo CMR 1 week later. Five animals comprised the control group, in which ex-vivo imaging was undertaken without any suppJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic ResonanceImproved co-registration of ex-vivo and in-vivo cardiovascular magnetic resonance images using heart-specific flexible 3D printed acrylic scaffold combined with non-rigid registration.PMC6785908FS/18/27/33543CL-2015-17-502ACF-2013-17-008EP/R010935/1EP/P01268X/1HICF-R10-698MR/N001877/1R01 HL129185WT 203148/Z/16/ZChubb HNiederer SRazavi RO'Neill MO'Neill LAnter ERoujol SRhode KPuyol-Anton EKing AByrne NTschabrunn CMukherjee RKNeji RBishop MJConnolly ARazeghi OWhitaker JNezafat RWilliams SEfalseImproved co-registration of ex-vivo and in-vivo cardiovascular magnetic resonance images using heart-specific flexible 3D printed acrylic scaffold combined with non-rigid registration.<h4>Background</h4>Ex-vivo cardiovascular magnetic resonance (CMR) imaging has played an important role in the validation of in-vivo CMR characterization of pathological processes. However, comparison between in-vivo and ex-vivo imaging remains challenging due to shape changes occurring between the two states, which may be non-uniform across the diseased heart. A novel two-step process to facilitate registration between ex-vivo and in-vivo CMR was developed and evaluated in a porcine model of chronic myocardial infarction (MI).<h4>Methods</h4>Seven weeks after ischemia-reperfusion MI, 12 swine underwent in-vivo CMR imaging with late gadolinium enhancement followed by ex-vivo CMR 1 week later. Five animals comprised the control group, in which ex-vivo imaging was undertaken without any supp2019-01-01T00:00:00Z2019 Oct2026-05-07T12:38:54.263Z2025-05-29T20:17:09.946ZS-EPMC67859083159756310.1186/s12968-019-0574-z