{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Himuro M"],"funding":["Japan Agency for Medical Research and Development","Daiichi-Sankyo","Japan Society for the Promotion of Science"],"pagination":["1979-1992"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6786006"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3(11)"],"pubmed_abstract":["Autophagy is known to play a pivotal role in intracellular quality control through the degradation of subcellular damaged organelles and components. Whereas autophagy is essential for maintaining β-cell function in pancreatic islets, it remains unclear as to how the cellular autophagy affects the homeostasis and function of glucagon-secreting α cells. To investigate the role of autophagy in α cells, we generated a mutant mouse model lacking Atg7, a key molecule for autophagosome formation, specifically in α cells. Histological analysis demonstrated more glucagon-positive cells, with a multilayered structure, in the islets under Atg7 deficiency, although metabolic profiles, such as body weight, blood glucose, and plasma glucagon levels were comparable between Atg7-deficient mice and control littermates. Consistent with our previous findings that Atg7 deficiency suppressed β-cell proliferation, cellular proliferation was suppressed in Atg7-deficient α cells. These findings suggest that α-cell autophagy plays a role in maintaining α-cell area and normal islet architecture but appears to be dispensable for metabolic homeostasis."],"journal":["Journal of the Endocrine Society"],"pubmed_title":["Cellular Autophagy in α Cells Plays a Role in the Maintenance of Islet Architecture."],"pmcid":["PMC6786006"],"funding_grant_id":["JP18gm0610005","16K15490","17K09848","17H04202"],"pubmed_authors":["Shiota C","Watada H","Miura M","Sasaki S","Suzuki L","Gittes GK","Katahira T","Fujitani Y","Goto H","Himuro M","Miyatsuka T","Koike M","Nishida Y"],"additional_accession":[]},"is_claimable":false,"name":"Cellular Autophagy in α Cells Plays a Role in the Maintenance of Islet Architecture.","description":"Autophagy is known to play a pivotal role in intracellular quality control through the degradation of subcellular damaged organelles and components. Whereas autophagy is essential for maintaining β-cell function in pancreatic islets, it remains unclear as to how the cellular autophagy affects the homeostasis and function of glucagon-secreting α cells. To investigate the role of autophagy in α cells, we generated a mutant mouse model lacking Atg7, a key molecule for autophagosome formation, specifically in α cells. Histological analysis demonstrated more glucagon-positive cells, with a multilayered structure, in the islets under Atg7 deficiency, although metabolic profiles, such as body weight, blood glucose, and plasma glucagon levels were comparable between Atg7-deficient mice and control littermates. Consistent with our previous findings that Atg7 deficiency suppressed β-cell proliferation, cellular proliferation was suppressed in Atg7-deficient α cells. These findings suggest that α-cell autophagy plays a role in maintaining α-cell area and normal islet architecture but appears to be dispensable for metabolic homeostasis.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Nov","modification":"2024-11-20T05:42:25.091Z","creation":"2019-11-05T08:11:18Z"},"accession":"S-EPMC6786006","cross_references":{"pubmed":["31620668"],"doi":["10.1210/js.2019-00075"]}}