{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Montoya A"],"funding":["Universidad Nacional de Colombia"],"pagination":["E74"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6789494"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(3)"],"pubmed_abstract":["The goal of our research is the development of algorithmic tools for the analysis of chemical reaction networks proposed as models of biological homochirality. We focus on two algorithmic problems: detecting whether or not a chemical mechanism admits mirror symmetry-breaking; and, given one of those networks as input, sampling the set of racemic steady states that can produce mirror symmetry-breaking. Algorithmic solutions to those two problems will allow us to compute the parameter values for the emergence of homochirality. We found a mathematical criterion for the occurrence of mirror symmetry-breaking. This criterion allows us to compute semialgebraic definitions of the sets of racemic steady states that produce homochirality. Although those semialgebraic definitions can be processed al"],"journal":["Life (Basel, Switzerland)"],"pubmed_title":["Computing the Parameter Values for the Emergence of Homochirality in Complex Networks."],"pmcid":["PMC6789494"],"funding_grant_id":["HERMES 35497 and 44048"],"pubmed_authors":["Agreda J","Cruz E","Montoya A"],"additional_accession":[]},"is_claimable":false,"name":"Computing the Parameter Values for the Emergence of Homochirality in Complex Networks.","description":"The goal of our research is the development of algorithmic tools for the analysis of chemical reaction networks proposed as models of biological homochirality. We focus on two algorithmic problems: detecting whether or not a chemical mechanism admits mirror symmetry-breaking; and, given one of those networks as input, sampling the set of racemic steady states that can produce mirror symmetry-breaking. Algorithmic solutions to those two problems will allow us to compute the parameter values for the emergence of homochirality. We found a mathematical criterion for the occurrence of mirror symmetry-breaking. This criterion allows us to compute semialgebraic definitions of the sets of racemic steady states that produce homochirality. Although those semialgebraic definitions can be processed al","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Sep","modification":"2025-06-01T02:41:26.926Z","creation":"2025-06-01T02:41:26.926Z"},"accession":"S-EPMC6789494","cross_references":{"pubmed":["31540188"],"doi":["10.3390/life9030074"]}}