{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chi L"],"funding":["NIEHS NIH HHS"],"pagination":["97002"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6792374"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["127(9)"],"pubmed_abstract":["<h4>Background</h4>Arsenic-induced liver X receptor/retinoid X receptor (LXR/RXR) signaling inhibition is a potential mechanism underlying the cardiovascular effects caused by arsenic. The gut microbiota can influence arsenic toxic effects.<h4>Objective</h4>We aimed to explore whether gut microbiota play a role in arsenic-induced LXR/RXR signaling inhibition and the subsequent lipid and cholesterol dysbiosis.<h4>Methods</h4>Conventional and antibiotic-treated mice (AB-treated mice) were exposed to 0.25 ppm and 1 ppm arsenic for 2 wk. Hepatic mRNAs were extracted and sequenced. The expression levels of genes associated with LXR/RXR signaling were quantified by quantitative real-time polymerase chain reaction (qPCR), and serum and hepatic cholesterol levels were measured. Liquid chromatograp"],"journal":["Environmental health perspectives"],"pubmed_title":["Lipid and Cholesterol Homeostasis after Arsenic Exposure and Antibiotic Treatment in Mice: Potential Role of the Microbiota."],"pmcid":["PMC6792374"],"funding_grant_id":["P30 ES010126"],"pubmed_authors":["Chi L","Lu K","Lai Y","Liu CW","Tu P","Xue J","Ru H"],"additional_accession":[]},"is_claimable":false,"name":"Lipid and Cholesterol Homeostasis after Arsenic Exposure and Antibiotic Treatment in Mice: Potential Role of the Microbiota.","description":"<h4>Background</h4>Arsenic-induced liver X receptor/retinoid X receptor (LXR/RXR) signaling inhibition is a potential mechanism underlying the cardiovascular effects caused by arsenic. The gut microbiota can influence arsenic toxic effects.<h4>Objective</h4>We aimed to explore whether gut microbiota play a role in arsenic-induced LXR/RXR signaling inhibition and the subsequent lipid and cholesterol dysbiosis.<h4>Methods</h4>Conventional and antibiotic-treated mice (AB-treated mice) were exposed to 0.25 ppm and 1 ppm arsenic for 2 wk. Hepatic mRNAs were extracted and sequenced. The expression levels of genes associated with LXR/RXR signaling were quantified by quantitative real-time polymerase chain reaction (qPCR), and serum and hepatic cholesterol levels were measured. Liquid chromatograp","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Sep","modification":"2025-04-21T23:27:34.874Z","creation":"2019-11-13T08:02:34Z"},"accession":"S-EPMC6792374","cross_references":{"pubmed":["31532247"],"doi":["10.1289/EHP4415"]}}